Two pig farms and two informal settlements are under quarantine due to an outbreak of classical or European swine fever, also known as hog cholera, the first since 1918.
Police have set up two roadblocks in the Hex River Valley, near Cape Town, to contain the movement of pigs and products.
Since the Department of Agriculture detected the outbreak last week, 700 pigs have died on the two farms, while 50 died in the informal settlements.
Symptoms include fever, lethargy, haemorrhagic skin lesions, vomiting and convulsions.
Western Cape Veterinary Services have since last week shot, disinfected and buried an additional 1,200 pigs on the two farms, said provincial director of veterinary services Gideon Bröckner.
The affected premises would now be disinfected, while no pigs or pig products would be allowed to enter or exit the area over the next four weeks.
Bröckner said members of the police, traffic department and disaster management would check vehicles for the transportation of pig products, both on the road between De Doorns and Touws River, and outside Worcester on the N1, until at least the end of next week.
