Explore
Communities in English
Advertise on Engormix

T-2 mycotoxin intoxication in piglets: a systematic pathological approach and apoptotic immunohistochemical studies

Published: September 22, 2022
By: María A. Quiroga, Miguel A. Risso, Carlos J. Perfumo / Institute of Pathology, Faculty of Veterinary Sciences, La Plata National University.
Summary

An experimental study was performed in order to analyze the histopathological findings of gastrointestinal mucosa and regional lymph-nodes in piglets intoxicated with T-2 toxin as well as the mechanism of T-2 induced apoptosis in the intestinal crypt epithelia. Sixteen piglets were divided into 4 groups receiving a single oral administration of T-2 toxin. Group A: 2.5 mg T-2/kg b.w.; group B: 2 mg T-2/kg b.w.; group C: 1.5 mg T-2/kg b.w.; group D: control group without toxin. Organ lesions were classified in grades 0 to 4 according with severity and were statistically analyzed. Apoptosis was examined in intestinal sections only in groups A and D. Group A piglets showed clinical signs and pathological changes related with those seen in circulatory shock. Microscopic lesions were observed only in pigs from groups A and B. In stomach, lesions consisted of congestion, hemorrhages and necrotic cells in the isthmus and neck regions. Submucosal edema and necrotic crypt epithelial cells were seen in duodenum, jejunum, ileum, cecum and colon. The greatest grade of lesions was observed in colon. In lymph node, grade of lymphocytes depletion and necrosis was significantly higher in cortex than paracortex. Apoptotic bodies were present in intestinal crypt cells, lymphoid cells from lamina propria and ileal Peyer´s patches. Apoptosis seems to be the mechanism involved in the development of intestinal lesions.

Key Words: T-2 mycotoxin, pig, apoptosis, pathology.

    

Abstract published in Brazilian Journal of Veterinary Pathology, 2009, 2(1), 16 - 22. http://www.bjvp.org.br/.

Related topics
Authors:
Dr. Carlos Perfumo
Universidad Nacional de La Plata - UNLP
Follow
Join to be able to comment.
Once you join Engormix, you will be able to participate in all content and forums.
* Required information
Would you like to discuss another topic? Create a new post to engage with experts in the community.
Create a post
Join Engormix and be part of the largest agribusiness social network in the world.
LoginRegister