James S. Nowick

INTRODUCTIONNovo29, a new antibiotic from a soil bacterium closely related to Eleftheria terrae, was recently reported. Novo29 is an eightresidue depsipeptide comprising a macrolactone ring and a linear tail. It is active against Gram-positive bacteria, including drug-resistant human pathogens, such as MRSA and VRE. Novo29 kills bacteria by inhibiting bacterial cell-wall synthesis, with no detecta ...