We will be present at:
September 18, 2021 to September 21, 2021
St Paul, Minnesota, United States
Clementine Marien
Clementine Marien
Marcq-en-baroeul, Nord-Pas-de-Calais, France

Microsaf® the new generation bacteria probiotic in poultry


Microsaf® is a unique association of three proprietary strains from 3 Bacillus species, carefully chosen to produce improvements in feed efficiency, gut function and microbiota, and overall growth performance in birds:

Bacillus amyloliquefaciens NRRL B-67647

Bacillus licheniformis NRRL B-67649

Bacillus pumilus NRRL B-67648

The performance of Microsaf® is enhanced by Germination Optimization Technology (GO Technology®),a new process designed to promote faster and stronger Bacillusspore germination. This maximizes the Microsaf® impact within the short transit time of 4-5 hours, which applies to most chickens.

GO Technology® is an exclusive patented technology (US 9,447,376, US 9,932,543 and EU application 14749483.5).

Microsaf® is a spore forming bacteria probiotic with a high resistance to feed processes, such as high-temperatures during pelleting or the heat treatment of mash feed.

Microsaf® Key Benefits in Poultry

In-vivotrials carried out in different parts of the world demonstrate that supplementing birds’ feed with Microsaf® can help to mitigate the negative effects of nutritional challenge or necrotic enteritis caused by Clostridium perfringens.

Compared in trials with two other Bacillus-based products, Microsaf® achieved higher levels of feed intake, improved FCR and the best return on investment (ROI).

Nutritional challenge

↑ Feed intake


↑ Body weight

Necrotic enteritis challenge

↑ Feed efficiency

↓ Mortality

↑ Body weight

Microsaf® Mode of Action in Poultry

Microsaf® is the association of 3 Bacillus species selected through a battery of screening tests from a library of proprietary strains.

These three Bacillus strains are chosen for their complementary mode of action. Microsaf® combines Bacillus amyloliquefaciens NRRL B-67647, which is the best performing strain to produce enzymes; Bacillus licheniformis NRRL B-67649, which is the best performing strain to produce lactic acid, and Bacillus pumilus NRRL B-67648, which is the best performing strain for phagocytosis activation. All three strains have a strong ability to inhibit major poultry pathogens, such as Clostridium perfringens, Escherichia coli (E. coli), Campylobacter jejuni and Staphylococcus aureus.

GO Technology® – Faster and Stronger Spore Germination

By the prior placing of key germinants within the spore for faster activation, GO Technology® can accelerate and synchronize Bacillus spore germination and deliver probiotic benefits to birds more efficiently.

GO Technology® has been developed to allow sporulated probiotics to germinate under challenging conditions due to the short transit time in chickens and to mitigate the negative impacts of acidic pH and bile salts which can delay spore germination.

Comparing Bacillus spores primed by GO Technology® to ones which are not primed, showed that GO Technology® innovation successfully accelerated and synchronized the germination of the three Microsaf® strains. This enabled primed Bacillus licheniformis spores to reach 90% germination in just 45 minutes, a level reached by only 10% of the spores in the control group.