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PRIMUN® Salmonella E Salmonella enteritidis vaccine for hens

PRIMUN® Salmonella E

Lyophilisate for use in drinking water for chicken

Substance:

Each dose contains: Live, attenuated Salmonella enterica subsp.enterica serovar Enteritidis-strain CAL10 Sm+/Rif+/Ssq-,1-6 x 10 8 CFU

Indications for use, specifying the target species

Replacement chicks (future layers and breeders): Active immunisation to reduce colonisation of internal organs (spleen, liver, caeca and ovaries) and faecal excretion of Salmonella Enteritidis field strains.

Dosage Regimen: A single dose from one day of age, followed by a second vaccination at 7 to 8 weeks of age and a third vaccination at 18-20 weeks at least 3 weeks before the onset of the laying period.

Onset of immunity: within 14 days of 1 st vaccination and within 4 weeks after the 2 nd and 3 rd vaccination. Duration of immunity: until 60 weeks after the 3rd vaccination, when used according to the recommended vaccination schedule

Immunological properties

To stimulate active immunity to Salmonella Enteritidis, phage type 4.

The vaccine strain is a natural metabolic drift mutant, i.e. is it lacks or does not express certain metabolic pathways which result in attenuation. The genetic basis results in defective ribosomal protein S12 affecting polypeptide synthesis (streptomycin resistance) and defective RNA polymerase affecting transcription of DNA to RNA (rifampicin resistance).

The vaccine strain also has attenuations that increase the permeability of the cell membrane for harmful agents such as detergents and antibiotics. This means the strain has poor survival in the environment and is highly sensitive to fluoroquinolones and unlike field strains is sensitive to erythromycin.

 

PRIMUN® Salmonella E
PRIMUN® Salmonella E