Scientifically Designed and Developed
Xylamax® is a unique high quality xylanase enzyme that helps producers improve animal nutrition and gut health in a safe and sustainable way. It has been scientifically developed to consistently deliver premium performance across a wide range of feed formulations, productionenvironments and practices used around the world.
An endo-1,4-beta-xylanase, Xylamax was developed by BRI scientists from a unique gene found in a naturally occurring fungal micro-organism. The primary function of xylanase enzymes is to break downxylans, a type of non-starch polysaccharide (NSP) found in the cell walls of corn and other grains, so that they are more easily digested by poultry. Xylamax performs this function extraordinarily well because of its unique protein structure and pH activity profile.
Xylamax Mode of Action
Research confirms that 450-500 kcal/kg of valuable energy in a typical poultry diet is not digestible. The addition of enzyme feed additives has been shown to make up to 30% (135 kcal/kg) of this energy digestible (Cowieson, 2010). Xylans are the most prevalent type of NSP in poultry feed grains, representing up to 43% of the total NSP content.
Xylanase enzymes hydrolyze glycosidic bonds in xylans that make up cell walls, resulting in the release of the encapsulated nutrients.
Unique Protein Structure Maximizes Energy Release
Xylans occur in two types, water soluble and water insoluble. There are two familiesof xylanase enzymes used in animal feed, GH10 which primarily hydrolyzes soluble xylans and GH11 which more effectively hydrolyzes both soluble and insoluble xylans (Berrin and Juge, 2008).
To maximize release of encapsulated nutrients in feed grains, the correct type of xylanase enzyme is required. For example, 98% of the xylan content in corn is insoluble. In order for poultry to digest a typical corn-SBM diet, a xylanase which targets insoluble xylans (GH11), such as Xylamax, is required.
Xylamax is a unique GH11 xylanase with an extended enzymatic site which allows for greater catalytic activity.
Unique pH Activity Profile Increases Nutrient Absorption
The Impact of Enzyme pH and Temperature Profiles
Feed digestion occurs mainly in the small intestine of poultry (duodenum, jejunum, ileum) as evidenced by the amount of time the digesta material remains in these areas of the bird’s gut. The majority of absorption of nutrients also occurs in the small intestine due to the presence of a higher number of villi, the site of nutrient absorption. For any enzyme to deliver maximum results, it needs to work optimally at the 5.7-7.0 pH range occurring in the small intestine (Sturkie, 2000). Xylamax is the highest activity enzyme in this range. Xylamax also exhibits activity in excess of 75% within the 40.6 43.0°C temperature range of the poultry gut.
The Impact of Digesta Viscosity
A highly viscous composition of the digested material in the bird’s intestine causes a decrease in the passage rate through the gastrointestinal tract. As a result, nutrient diffusion and absorption in the foregut is reduced, and unabsorbed nutrients are allowed to enter the hindgut where they facilitate the proliferation of detrimental bacteria. High digesta viscosity further impairs poultry nutrition by reducing feed intake.
Naturally Improves Gut Health
Not only do undigested xylans limit nutrient availability, increase digesta viscosity and reduce nutrient absorption and utilization by the bird, they may also contribute to the growth of intestinal pathogens that thrive on undigested nutrients in the feed. Proliferation of these pathogens is associated with compromised morphological development of the gut mucosa, pathogen-induced gut inflammation, oxidative stress and tissue damage. By effectively degrading xylans found in grains, Xylamax improves the overall gut health of animals.
Impact on Mucosal Morphology and Growth of Pathogens
By effectively attacking the detrimental effects of xylans, Xylamax limits growth of pathogens in the intestine while improving the bird’s nutrient absorption and utilization because of higher nutrient digestibility and improved gut function, as indicated by increased villi height in the presence of Xylamax in feed.
Decreased Severity of Necrotic Lesions
Necrotic Enteritis, characterized by Clostridium perfringens, costs the global poultry industry about $2 billion annually (Ducatelle and Immerseel, 2010). Necrotic Enteritis causes necrotic lesions in the intestinal tract, poor digestion, reduced weight gain, increased FCR, and even death. In a 42-day pen trial, birds were fed a typical corn-soy diet and were challenged with C. perfringens (107/bird). Necrotic lesions in birds supplemented with Xylamax were significantly less severe than in birds that were not supplemented with the enzyme, contributing to the overall gut health of the birds.
Naturally Improves Gut Health
Reduction of Oxidative Stress and Mucin Secretion
A healthy gut can be measured not only by mucosal morphology but also by indicators of oxidative stress, such as malondialdehyde (MDA). Increases in MDA have been associated with suppressed gut development, reduced growth performance and poor feed efficiency in broilers. Supplementation of Xylamax in broiler feed has been shown to reduce MDA concentrations in serum and mucosa.
Creation of Prebiotic Effect
In addition to limiting the growth of pathogens through improved nutrient digestibility, Xylamax helps maintain the healthy microbiota by producing xylo-oligosccharides (XOS), which preferentially promotes the growth of beneficial bacteria, such as Bifidobacterium and Lactobacillius in the foregut. This prebiotic effect offers the host additional protection against potential pathogenic challenges, allowing more consistent performance in various commercial settings.
Versatile Solution, Consistent Performance
Xylamax delivers consistently high performance across a range of feed ingredients as shown in animal feeding trials conducted by internationally recognized independent poultry research institutions. All BRI products are manufactured in accordance with world class GMP and FAMI-QS standards to ensure a consistent high quality product from batch to batch.
Flexible Feed Formulation Strategies
Birds treated with Xylamax are heavier on average than birds not treated with an enzyme. Furthermore, a larger proportion of the birds are closer to the average weight, improving flock uniformity. Xylamax treatment contributes to a heavier, less variable flock.