Robert F. Wideman

INTRODUCTIONTight junctional complexes comprise a key component of the intestinal barrier by sealing the apical surfaces of adjacent epithelial cells. “Leaky” tight junctions provide paracellular portals through which pathogenic bacteria can cross the gastrointestinal epithelium and ultimately enter the systemic arterial circulation. This process of bacterial leakage across the in ...

Introduction.   Bacterial chondronecrosis with osteomyelitis (BCO) is a leading cause of lameness in commercial broilers produced in North America (1, 2, 9). The lesions most often occur in the proximal femora and tibiae and are associated with osteochondrotic microfractures and clefts in rapidly growing broilers. Bacteria distributed hematogenously exit the bloodstream and colonize the str ...