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Use of plant extracts against necrotic enteritis - Mechanism of action

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October 12, 2021
As there lot many researches in Ancient Ayurveda there are Many plant and their extracts have Good antibacterial and Antiviral properties . They also have effect on Parasitic infections too. Coccidiosis is really a dangerous threat as its subclinical form is a predisposing factor to trigger the penetration of anaerobic bacteria and cause enteritis in Animals.
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Teresa M. Agulles Teixidó Teresa M. Agulles Teixidó
Operations Director
PlusVet Animal Health PlusVet Animal Health
Qingdao, Shandong [Shantung], China
October 15, 2021
Indeed Ayurveda is a continuous source of inspiration for Western phytotherapists!
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October 21, 2021

Can you explain how plants possess most and broad spectrum powerful antibacterial activities? We can educate the users to reduce the use of antibiotics and can divert towards the use of phytochemical products.

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Teresa M. Agulles Teixidó Teresa M. Agulles Teixidó
Operations Director
PlusVet Animal Health PlusVet Animal Health
Qingdao, Shandong [Shantung], China
October 22, 2021
Dr. Atul Deshmukh Plant extracts have multiple mechanisms of action against pathogenic microorganisms: inhibition of quorum sensing, direct toxicity on the cell wall, alteration of protein synthesis, reduction of the levels of ATP, reduction of the intracellular pH, and more. These mechanisms of action can happen at the same time, that's why the spectrum of action of plant extracts may be broader than synthetic antibiotics.

Also, these mechanisms are less specific than the mechanism of action of synthetic antibiotics, that's why resistance to plant extracts is rare.

We wrote an article in our website ( plusvet.eu) that might interest you, called "Essential oils: Mechanism of action on pathogenic bacteria".
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October 23, 2021
Teresa M. Agulles Teixidó

Thank you Ms.Teresa
I will go through the same on the website.
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Zahed Abbasi Zahed Abbasi
VETRINARIAN
October 25, 2021

Hi Ms Teresa:
There is a question , do you mean that plant extract can be replaced and be used instate of antibiotic when there is mortality from necrotic enteritis in a flock?
I think we can use plant extract as gut health enhancer to prevent and control of necrotic enteritis especially subclinical form of it, but when we are faced disease and mortality use of antibiotic is a must.
I'll wait for your recommendation.

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Teresa M. Agulles Teixidó Teresa M. Agulles Teixidó
Operations Director
PlusVet Animal Health PlusVet Animal Health
Qingdao, Shandong [Shantung], China
October 26, 2021
Zahed Abbasi Dear Mr. Zahed, yes, we have many experiences in which we managed to control necrotic enteritis only with plant extracts, without antibiotics, especially in layers during the laying period, when antibiotics cannot be used for residue concern.

We recommend our products at a lowest dose for NE prevention and at the highest dose for treatment
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alberto profumo alberto profumo
VETERINARIAN
October 26, 2021

Zahed Abbasi i agree with you. When there is mortality the disease is acute and the only solution is antibiotic of first choice then, after an antibiogram, the right antibiotic. Surely working in prevention with plant extract, lactobacillus used as probiotics and a good management will help to prevent clostridiosis. In my opinion as a VET working with farm animals since 1997, we must use all the "weapons" that we have.

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October 27, 2021
alberto profumo Dear Dr. Alberto, you are absolutely right. Moreover, the problem of the reproduction of Clostridia is not only a veterinary problem, but also a feed problem. After all, necrotic enteritis does not arise just like that. As a result of feeding errors, favorable conditions are created for the reproduction of Clostridia. These are stagnant phenomena in the intestine, a low speed of movement of the chyme, the presence of an excess substrate for feeding Clostridia, a violation of the energy-protein ratio in feed, a high content of anti-nutrients - non-starch polysaccharides (NSP), improperly selected feed enzymes for the diet, and much more. If these factors are taken into account, then maybe Clostridiosis will not occur and the feed conversion will improve. Well, of course, veterinary treatment is also important, but this is already when the bird has clinical symptoms of the disease. But any case, it is better not to bring the bird to clinical symptoms of necrotic enteritis.
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Miguel A Pérez Miguel A Pérez
Gerente de Comercio Exterior
October 29, 2021
Dear Zahed Abbasi

Yes, A plant extract "stabilizaed" can replace an antobiotic. And I did say "stabilised". Stabilising a plant extract is not a simple task in batch manufacturing, and that is why there are still many doubts about the efficacy of natural products.

We have been using for a long time with remarkable success an olive by-product extract with a high concentration of Maslinic Acid, which has an inhibitory effect on the activity of the serine-protease CspB, responsible for activating SleC in the spore germination process of Clostridium spores.
spore germination process of Clostridium.

I hope that helps

Best Regards,
Miguel.
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Talaat Mostafa  El-Sheikh Talaat Mostafa El-Sheikh
T. M. El-Sheikh Prof. Dr. of Poultry Production, Head of Animal & Poultry Prod. Dept.
November 14, 2021
which the plant is the best and its background in this area
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Teresa M. Agulles Teixidó Teresa M. Agulles Teixidó
Operations Director
PlusVet Animal Health PlusVet Animal Health
Qingdao, Shandong [Shantung], China
November 15, 2021
Talaat Mostafa El-Sheikh Dear professor, it's hard to say which plant is the best, we use a combination of plants in the formula, some have microbiocide effect and others have prebiotic, antioxidant and antiinflamatory action. The complementary activities of all the plants are effective to restore gut health.
Reply
Miguel A Pérez Miguel A Pérez
Gerente de Comercio Exterior
November 16, 2021
Talaat Mostafa El-Sheikh Dear professor, in our case we use sub-products from olive oil extraction.
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