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Phileo launches new generation multi-species bacteria probiotic in poultry

Published on: 02/08/2019
Source : Phileo Lesaffre

Microsaf®, a multi-species bacteria probiotic, will be officially launched by Phileo Lesaffre Animal Care in Atlanta (Feb 12-15, 2019) during IPPE 2019, giving poultry professionals an exciting new route to improved feed efficiency, gut health and growth performance. Marcq-en-Baroeul, France (February 7, 2019). The new probiotic is based on a unique combination of three proprietary strains ...

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Badal Singh Badal Singh
veterinary science
February 8, 2019

Good evening.

Please explain which strain of probiotic is better in layer birds. Does it depend on feed ingredient?

Reply
Alain Riggi Alain Riggi
Global Poultry manager
Phileo by Lesaffre Phileo by Lesaffre
Nord-Pas-de-Calais, France
February 8, 2019

Dear Badal Singh,
Generally, the choice of probiotic species depends on the production type.

In broilers, most of the time, the feed is pelleted and the high temperature kills most of vegetative forms of probiotic bacteria. it is why sporulated bacillus are mostly used in such a production: Bacillus subtilis, Bacillus licheniformis, etc...They are resistant to feed pelletization process.
These strains don't grow in the gut (or just a few) and are effective in the gut as long as we supplemented the feed.

In layers, unless the feed is heat treated, it is possible to use vegetative forms of probiotic bacteria, like lactobacillus (Lactobacillus salivarius, L. reuteri, or even Enterococcus faecium). The advantage is that they colonize the gut and are useful in starting phase when the gut microbiota is not mature enough to protect young animals from Salmonella contamination for instance.
These bacteria are also quite useful when there is a shift in the gut microbiota, after stress for instance, and they can help to recover faster a good balance of this microbiota.

In the probiotics group, we should not forget the role of live yeast in layers, which can help a lot to improve the gut health of the hens, and thus the egg production.

In conclusion, the use of one or the other kind of probiotic depends more on which process is applied, and on the objective of supplementation (zootechnical or pathogen prevention). The features of the probiotics will complete this choice.

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Badal Singh Badal Singh
veterinary science
February 11, 2019
Alain Riggi Thanks for given information ...
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Shah Alam Shah Alam
Sales manager
February 27, 2019
Alain Riggi
Thanks a lot for your nice information. Be good.

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Md. Abdullah Ansari Md. Abdullah Ansari
Doctor of Veterinary Medicine
February 20, 2019
Organic acids as feed additives are using in layer feed which keep the gut ph normal and this condition creates the good microbiota in gut. Is there any synergistic effect of probiotics with organic acids in the gut and what's the mechanism?
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Alain Riggi Alain Riggi
Global Poultry manager
Phileo by Lesaffre Phileo by Lesaffre
Nord-Pas-de-Calais, France
February 20, 2019
Md. Abdullah Ansari
Dear sir,
Organic acids can indeed regulate gut's pH, but their real effect is more due to the following:
Organic acids, in their un-dissociated form, penetrate the microbial cell wall.
Due to the high intracellular pH, a large portion of the organic acids will dissociate and release their hydrogen ion (H+) leading to acidification of the cell content.
Getting rid of these H+ ions takes an enormous amount of energy which eventually leads to cell death of the targeted bacteria.
If we consider an association with probiotics, first we have to take care about compatibility between them.
But generally, probiotic bacteria, as they release themselves acids, are resistant to organic acids. Some integrators are adding those 2 products in their feed.
We certainly have a cumulative effect, but I have no information to confirm any synergy between organic acids and probiotic bacteria.
Kind regards.
Reply
February 26, 2019

Alain Riggi, I think we have serious problem on the organic acid form in the gut. Most of organic acids are almost completely dissociated in gut pH, like butyric acid, the pKa value is 4.8, meaning it is only 50% the acid supplied in form of undissociated form at pH 4.8. and keep reducing the portion at higher pH. As we all know, poultry gut is resided by pathogen mostly in hind gut, which the pH is around 7, where butyric acid is almost completely in dissociated form and automatically losing its antimicrobial effect.

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Rodel Villaraza Rodel Villaraza
Animal Nutritionist
March 13, 2019

afriadi , good observation however there other organic acid that can maintain its functions and others have technology to coat these acids so that they can reach the part that needs most of the acidification.

And butyric acid is not used for basic acidification. Synergistic combination of organic acids and some inorganic acid will do the trick.

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Rodel Villaraza Rodel Villaraza
Animal Nutritionist
March 13, 2019

Alain Riggi - nice informative discussion regarding organic acids sir. Probiotic can survived even with organic acids. For me I would use combination of organic acids and probiotic to assure good growth. The organic acid would serve 3 purposes. One is what you have discussed in your above response, the other would create an environment to active digestive enzymes and propagation of good bacteria. Initially, the organic acids would work overtime until the optimum population of the probiotic can perform the competitive exclusion against bad bacteria.

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February 20, 2019

Dear sir,
What are the benefits of Co enzyme CQ 10 along with natural vitamin C, organic acids, essential oils, and copper sulfate in layer birds?

Reply
Alain Riggi Alain Riggi
Global Poultry manager
Phileo by Lesaffre Phileo by Lesaffre
Nord-Pas-de-Calais, France
February 20, 2019

Subodh kumar singh
Dear sir,
Perhaps someone who is more used to work with these products can reply to your questions.
Kind regards.

Reply
Steffen Hansen Steffen Hansen
Animal Nutritionist
February 21, 2019
How did you investigate germination, in vitro or in vivo? Have you carried out efficacy trials comparing your bacillus strains with or without the GO Technology?
Reply
Rober Kemperman Rober Kemperman
Head Microbiology
Phileo by Lesaffre Phileo by Lesaffre
Nord-Pas-de-Calais, France
February 25, 2019

Dear Steffen,

As I presented during the IPPE, we have investigated germination extensively under in vitro conditions showing enhanced germination when spores have been treated with the GO technology.

In vivo, we have yet to verify if we observe a difference in vegetative cells versus spores after ingestion of GO technology treated spores versus regular spores. We do expect though that vegetative cells will be present in higher numbers for the treatment with GO technology.

We have also compared the efficacy of the bacillus strains with and without GO technology. For example, in a mollusks study, we showed the clear benefit of the GO technology on survival and growth. Likewise in a oyster larvea study, we saw a similar benefit on enhanced survival when using GO technology treated strains versus non treated spores. In poultry, we have not always done comparative studies. The studies we have performed suggest a benefit of the GO technology in a challenged situation.

Kind regards.

Reply
February 27, 2019

I believe that in choosing organic acids it is important to consider the Ka of the acid.
Normally, a mixture of organic acids of different Ka works better than a single acid. This mixture of different Ka organic acids guarantees acidification of all parts of the upper digestive tract.

Reply
February 28, 2019
Alfredo Navarro De Andrade Dear Alfredo, yes it is. Mixture of OA is better than single OA. Also is reason to add appropriate salts: formiate, propionate, butyrate and others.
Reply
Rodel Villaraza Rodel Villaraza
Animal Nutritionist
March 13, 2019

Are multi species much more effective than single strain even if they are both spore-forming?

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