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Heat stress: underlying mechanism and mitigation by yeast paraprobiotics

Published on: 05/29/2018
Author/s : Dr. Ruth RASPOET

Heat stress pathophysiology As birds are homeothermic animals, they are able to maintain a relatively constant body temperature by balancing the production and dissipation of heat within their body. The maintenance of a constant body temperature is regulated by thyroid hormones of which the concentration is regulated by the hypothalamus – pituitary – thyroid axis (HPT) of the neuroe...

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May 29, 2018
Thank you for sharing this good work.
Reply
Atef Abou Zead Atef Abou Zead
professor of viral poultry diseases
May 30, 2018
Thanks
Excellent review
Reply
Atef Abou Zead Atef Abou Zead
professor of viral poultry diseases
May 30, 2018
But I would to ask what is the best for heat stress betaglucan or mannan oligosaccharides?
Reply
Phileo by Lesaffre Phileo by Lesaffre
Nord-Pas-de-Calais, France
June 1, 2018
Dear,

For heat stress mannans will be more adequate then B-glucans
B-glucans have an anti-inflammatory effect and will help to preserve tight junctions. However, mannans seem to have a broader effect as they help to maintain gut integrity and are able to bind different types of pathogenic bacteria. As such, translocation of bacterial fragments will be reduced and the immune system will be less stimulated.
Reply
Muhammad Salman Akram Muhammad Salman Akram
Doctor of Veterinary Medicine
June 4, 2018

Ruth Raspoet which yeast you use in safmannan?

Reply
Phileo by Lesaffre Phileo by Lesaffre
Nord-Pas-de-Calais, France
June 7, 2018
Safmannan is a premium yeast fraction coming from a proprietary saccharomyces cerevisiae bakery strain. Its unique manufacturing process guarantees more than 20% mannan-oligosaccharides and more than 20% ß-glucans. This batch to batch consistency leads a consistent effect.
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June 2, 2018

Dear all, stress generally and heat stress, for instance, has a lot of aspects. Regulation by hormones is only one of these aspects. The same important is hyperosmotic stress, dehydration of the cells. When it is not enough water inside the cell, hormones and immunostimulators will be not effective. In my opinion, it is a reason to combine yeast glucans of mannans with the cell osmolytes like betaine.

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Dr Ajay Bhoyar Dr Ajay Bhoyar
Global Poultry Manager
Novus International Novus International
Missouri, United States
June 4, 2018

Excellent information from all the contributors. Dr. Fiodor has mentioned a very important point in heat stress management. Indeed, both the poultry house management (lowering house temperature, managing feeding time, air movement, etc) as well as nutritional adjustment (nutrient density and source of nutrients, inclusion of electrolytes and Vitamin C, etc) plays a vital role in lowering the impact of heat stress. A natural response to heat stress by poultry is to reduce the feed consumption, which ultimately affects performance. The source of methionine can also make a difference during heat stress. HMTBa as a source of methionine has been shown to be more effective than DLM in preventing the characteristic depression in bird’s performance during heat stress. Since HMTBa is absorbed by diffusion, and there is no energy requirement or heat production associated with diffusion, birds are able to better absorb HMTBa during heat stress with a minimal amount of physiological stress. This aspect is critical as the absorptive surface area of the small intestine is reduced by high temperatures and this may play a role in performance during and following heat stress.

There is more information available here: http://www.novusint.com/Products/alimet

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Pat Welch Pat Welch
BS = Microbiology, MS = Physiology (Microbiology
Novus International Novus International
Missouri, United States
June 6, 2018
Dr Ajay Bhoyar This is especially important in tropical and sub-topical climates where reducing heat increment plays an important role in reducing metabolically induced heat stress.
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June 5, 2018
Very informative.
Reply
Raul Cortes Raul Cortes
Veterinary Doctor
Pancosma SA Pancosma SA
Geneve, Switzerland
June 5, 2018

Mannan and B-glucans, also proteins are part of Yeast wall that you may not spare. This mix of product are the key part of yeast attach to TLR2-Dectin1 receptor to stimulate IgA production at peyer patches. So Yeast walls are yeast Wall there is no Mannan free product or b-glucan free products that lead to IgA production.
It is clear in your trials that the use of yeast wall help the bird to cope with heat stress by the effect of this high IgA concentrations in the intestine (as you mention in your trial and some other done). Gut integrity it is the main target to achieve in heat stress.

Reply
Martin Smith Martin Smith
Animal Nutritionist
Evonik Animal Nutrition Evonik Animal Nutrition
Hessen, Germany
June 6, 2018

Heat stress continues to be a challenge, and any contribution to knowledge is welcomed. However, I would correct some of the points raised recently. Use of methionine sources will inevitably reduce heat stress, as correct formulation to SID amino acids will reduce crude protein content and thus energy expended in excreting excess nitrogen.
The choice of methionine source needs to account for this. As HMTBa, in reality, has an average BE of only 65% compared to DL Methionine, M+C deficiency is a possibility if higher BE values are used. Furthermore, the assertion that HMTBa is “more effective than DLM in preventing the characteristic depression in bird’s performance during heat stress” is not correct. Neither is the assertion that “HMTBa is absorbed by diffusion”. One should consider Maenz and Engele-Schaan (J. Nutr. 126, 1438-1444 1996) and Mitchell and Lemme (International Journal of Poultry Science 7 (3): 223-233 2008) as but two examples of the large body of work confirming that all methionine sources are transported by active-transport processes; and that response of birds to heat stress is not affected by methionine source.
Effective formulation, using accurate and precise digestible nutrient values, is undoubtedly a useful tool in reducing the effects of heat stress. Use of lipids as energy sources rather than carbohydrates; and use of salts such as potassium carbonate are more likely to provide relief.

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Peter Ssenkungu Peter Ssenkungu
Director
June 6, 2018

All this aside as a farmer and with some nutritional knowledge in tropical areas in Uganda... I have observed better results in tropical conditions for Layer, especially with HMTba usage.

The claim and not sure but the observation is better tropical performance in Layers on HMTba

Reply
Forest Lin Forest Lin
General manager & Sales Director China
Pancosma SA Pancosma SA
Geneve, Switzerland
June 6, 2018

Heat stress is really a headache for farms, the integrated solutions can work well only, so the capsicum can contribute some works along with other solutions according to Pancosma's numerous research for many years, you will see the result if you can try with extract.

Reply
Raul Cortes Raul Cortes
Veterinary Doctor
Pancosma SA Pancosma SA
Geneve, Switzerland
June 6, 2018
Heat stress make a lot of change in the animal. One that it is more important for live and performance is that the antioxidant "bag" is reduced because lack of this product in diet. To cope with this, the bird increase (?) the production of antioxidant enzymes as glutation peroxidase, but this need not only Se but Glutation. Cysteine needed for this glutation comes from metil-cicle that is push by met, but more by betaine. Betine is the only know product that may help to increase glutation production. How HMTb join this metil-cicle it may be the possible role in heat stress. Met do not increase glutation production.
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June 7, 2018
Impressive!
Reply
Begerano Albert Begerano Albert
Animal Nutritionist
June 7, 2018

Farmers should study the direct effect of betaine, in reducing stress under heat stress condition, there are few types of betaine, it seems that the natural source is more efficient.

Reply
Phileo by Lesaffre Phileo by Lesaffre
Nord-Pas-de-Calais, France
June 7, 2018

It must be kept in mind that YCW solutions like Safmannan, will have a much broader and more efficacious effect. Safmannan is able to bind pathogenic bacteria and will thus control the growth of opportunistic bacteria. Additionally, it will assist in the preservation of the tight junction integrity and in that way control bacterial translocation and gut inflammation. The control of gut inflammation is key in the mode of action to control the effects of heat stress.

Reply
Slausgalvis Virginijus Slausgalvis Virginijus
Veterinary Doctor
June 7, 2018

Thank you Fiodor. Colleagues.

Reply
June 9, 2018

Thank you for this information.

Reply
June 12, 2018
As there will be any effect of dubbing in hen heat regulation?
B/c comb may have a role in heat dissipation .isn,t?
Suggestion please?

Plus
Feeding very earlier at morning can effect or not?
Although if you have an environmentally control house?
I mean cost of temperature lowering.
Reply
June 12, 2018
Yogurt will do the job.
As will as if we lower the gut PH we can also cope that.
Reply
Ricardo Barretto Toledo Ricardo Barretto Toledo
Sales Manager – Americas
ICC Brazil ICC Brazil
Sao Paulo, Brazil
June 13, 2018

When we talk about Yeast Cell Wall (YCW) and its benefits to mitigate heat stress, It's important to consider a YCW source that originates most as possible indigestible fibers (MOS and B-Glucans), as what we look for it's a YCW that is able to reach the intestine without being digested on the way through. Otherwise, we will have those sugars digested in the rumen and no effect as expected. We can find in the market such indigestible options and the product ImmunoWall its one of that most indigestible YCW available (with min. 30% B-Glucans and 17% MOS). We have some data to share in case of interest. Best regards.

Reply
June 18, 2018

Ricardo Barretto Toledo
Dear Ricardo can you share the data for monogastrics?

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