Chris Morrow talks about mycoplasma vaccination in layers

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January 19, 2021
If you want more details about vaccination

http://www.bioproperties.com.au/!Pages/Publications/Documents/DOC-Bulletin-2020-01.pdf

If you want information on the Antibiotic sensitivity survey in Asia in MG and MS

Morrow CJ, Kreizinger Z, Achari RR, Beko K, Yvon C, Gyuranecz M. Antimicrobial susceptibility of pathogenic mycoplasmas in chickens in Asia. Vet Microbiol. 2020 Nov;250:108840. doi: 10.1016/j.vetmic.2020.108840. Epub 2020 Sep 19. PMID: 33068825.
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Muhammad Kashif Muhammad Kashif
Veterinary Doctor
January 19, 2021
Chris Morrow i need this article and please respond to my comment about vaccination of layers dudring rearing
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March 10, 2021

Chris Morrow, Thank you so much for the explanation of the eye drop vaccination for mycoplasma and I appreciate it and will mandate it as a way of improving my layer's quality and health.

Regards,
Daniel.

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Muhammad Kashif Muhammad Kashif
Veterinary Doctor
January 19, 2021
How many shots of Live vaccine or killed in layers and at what age and which vaccine you will prefer Dr. Morrow specially for MG control as it is a problem in Pakistan
If you remember you chaired session in WVPAC 2007 Beijing Where i presented on gentamicin toxicity it was my first international presentation
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January 20, 2021

Muhammad Kashif The live vaccines colonise the birds for life - you only need one vaccination. You should also vaccinate for MG and MS. MS can mimic anything MG can do.
ts-11 and MSH can be used from 3 weeks of age. Immunity may take 5 weeks to develop and you need to not use antibiotics after vaccination.

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Muhammad Kashif Muhammad Kashif
Veterinary Doctor
January 22, 2021
Chris Morrow Thanks
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David Burch David Burch
Doctor of Veterinary Medicine
January 24, 2021
I could not agree more Chris, that laying flocks should be vaccinated, especially in high risk areas. We normally consider MS to be less of a clinical problem but this has led it to be quite widely spread. The Dutch have made major efforts to reduce its incidence of infection in poultry in general but also in layers, which has proven more difficult. In conjunction with virus infections, such as IB and low path AI, we have seen some significant impacts on mortality and production with MS.
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Muhammad Kashif Muhammad Kashif
Veterinary Doctor
January 19, 2021

What is your opinion about F strain vaccination in layers?

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Nimer Natsheh Nimer Natsheh
Veterinary Doctor
January 23, 2021

it is an excellent vaccine for protection against MG with a good titer.

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January 24, 2021

Chris Morrow due to commercial reasons if all the commercial layer farmers in an area can't adopt the M.g control strategy with M.g vaccine. A few farmers using M.g vaccine should adopt live M.g vaccine or killed M.g vaccine is the safest solution then?

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Dr Kibiike David Dr Kibiike David
Bachlor. Veterinary Medicine
January 25, 2021

Thanks for all the responses, on my farm I experienced some infections a year ago. I depleted made did a though clean up disinfected and then took a 3 month without stocking.
After that i stocked and my birds were doing very well. In the sixth week, I did vaccination using a live Mycoplasma MS. I did a repeat at 9th week.
A week ago I got an attack of the infection at age of 14 weeks. I have been treating and they have cleared. I first used Tiamulin for 3 days there was no effect at all the infection was just progressing. I have now controlled it . my problem why did I get this attack even after vaccinating .
.

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January 25, 2021

What should be the Multi-age commercial layer (M.g) control strategy?

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January 26, 2021

1) you should control MG and MS with the same strategy. (freedom, vaccination, or antibiotics)
2) you should source replacement that is mycoplasma free
3) if your farm is multiage then you should rear stock remotely (2 km away from other poultry) and vaccinate them for the challenges they will get when they are moved to the multiage site.
4) Use live MG and MS vaccine - one dose. Don't use killed vaccines - don't worry about serology after vaccination and don't give the birds antibiotics unless they have clinical signs and if they do have clinical signs, get a diagnosis - DIVA PCR

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January 26, 2021
Chris Morrow if we have the same place for rearing and production then killed M.g vaccine can be a option?
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March 10, 2021
A very sensitive vaccination and will work for me and all farmers within the global .

Thank you Dr


Regards
Daniel
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Kamalmousa Ghedan Kamalmousa Ghedan
Animal Health Technologist
April 9, 2021
What about vaccination in flock show seroconversion of about 5-10% and pcr is negative?
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April 11, 2021
The vaccines have different kinetics with serology and PCR
MSH tends to increase in pan species PCR to 100% about 8 weeks post vaccination and stay high for the life of the bird. DIVA PCRs are less sensitive than pan species PCRs in general.
ts-11 initially increases in pan MG PCRs to about 4 week post vaccination peaking at 40% and then decrease again to rise as the birds come into lay and peak higher to nearly 100% PCR. Again DIVA PCRs are less sensitive.
Serology can remain flat negative till the birds are coming into lay and then rising - SErology is useless for monitoring vaccinated flocks - PCR is the only test that will give definitive answers.

So without knowing the timing of your testing it could be normal.
But you could be not vaccinating effectively and here you must consider antibiotic usage, cold chain and application (must be eyedrop), immunosuppression, etc. Are you having any clinical signs?
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April 13, 2021

Mycoplasma has been a problem to layer's farmers. How can eradicate it or prevent (consider to options). Preventing and controlling. How can we help to our best acknowledgment using our professional distinct.

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Dr Kibiike David Dr Kibiike David
Bachlor. Veterinary Medicine
April 14, 2021
I am a commercial layer farmer , I tried all biosecurity and vaccination however i have not managed to come with good results.

At my farm i do vaccinations and still end up with the problem. what am doing now is only biosecurity with treatment. this is very expensive and makes the enterprise very uneconomical.
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April 14, 2021
please email me and tell me what country you are in.
Chris.morrow@bioproperties.com.au

I will see if I can help you

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April 19, 2021
I'm in Ghana, Kumasi
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April 20, 2021
Dzugble DaCosta Well I am pretty sure you cant get MSH in Ghana. Just controlling MG with live vaccination gives you less than half of the control of mycoplasmosis needed as if you use antibitoics to control the effects of MS then this will interfere with the live MG vaccine protection.
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April 19, 2021
yes.

are the live Mycoplasma vaccines Mg ts11 is useful in preventing challenges during the peak of production.

is the role of killed vaccine is critical in breeders.
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April 19, 2021
Dr/ Mohamed Hassan Salem Live vaccine is important as is biosecurity. Killed vaccines are not important.
Killed vaccines have been shown to decrease trachael populations, decrease vertical transmission and some other systemic effects. They make a lot of humoral antibody and this can be turned into maternal antibody but humoral antibody has little effect on trachael populations and maternal antibody has not be shown to protect the day old chick from infection. (Levisohn and Kleven suggested that it may increase vertical transmission by keeping vertically infected embryos alive to hatch rather than ending up as late deads).
There are very few studies of live dead combinations and none with any clear positive effects of the combination. Glisson and Kleven study in 1984 should possible interference with F strain only having better protection after challenge than F and killed. Killed vaccines are being phased out by manufacturers. They have been used also to hide the infected status of flocks. The duration of immunity seems to be about to 40 weeks.
Live vaccines can prevent airborne challenge from estabilshing, stop vertical transmission (F strain is often vertically transmitted and causing problems in progeny) and provide protection for the life of the bird.
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Taha Taibeh Taha Taibeh
Veterinary Doctor
April 26, 2021
Why we face some high positive ms titer while it was negative for Mg without affecting the performance..
We use monthly prevention drug program.

Thanks Dr. Chris
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April 27, 2021
Taha Taibeh Antibiotic resistance in the MS? or using erythromycin which has no effect on MS.
and many other reasons.
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April 27, 2021
Taha Taibehno MG challenge - jeje
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Taha Taibeh Taha Taibeh
Veterinary Doctor
April 27, 2021
Chris Morrow appreciate your help
Actualy we use tylosin or tylmicosin..
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Aripin Drh Aripin Drh
Poultry Health breeding Japfa Indonesia
May 9, 2021
How are you Mr. Criss Morrow.
I thawed both the MG TS11 vaccine and the MS_H vaccination vaccine produced by Properties simultaneously according to brocure in warm water, temperature of 33-35 degrees Celsius it took 6 minutes from the frozen vaccine to thaw. Is the temperature right, safe or does not damage the vaccine? explanation please.
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May 9, 2021
Aripin Drh This is typical of vaccine that has been stored at -20. You can do this but you cant store the vaccine for more than 4 weeks at -20 and you should not use a domestic freezer that is frost free. Please email me chris.morrow@bioproperties.com.au so I can send you a special thermometer we are making for thawing.
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