Explore
Communities in English
Advertise on Engormix

Prophylactic targeting gut neuroimmunological axis to increase resistance to bacteria in layers

Published: March 14, 2022
By: M. Mellata / Iowa State University, Ames, IA, USA.
Summary

Poultry serve as a major reservoir for bacterial Enterobacteriaceae pathogens like Salmonella and Escherichia coli, which are a food safety concern. Although many probiotics are beneficial to poultry productivity, they induce poor host antimicrobial responses against enteric pathogens. We showed that some probiotics can even increase the level of Enterobacteriaceae in the chicken gut by increasing the level of norepinephrine. Furthermore, some bacteria like Salmonella actively promote immunotolerance in the chicken gut, which prevents antibacterial host responses and subsequently results in fecal Salmonella shedding and contamination of poultry products. Thus, novel prophylactics which can stimulate host intestinal responses and overcome these immunotolerant mechanisms to clear intestinal Enterobacteriaceae like Salmonella are needed. Our study demonstrates that prophylactics can alter intestinal immunological responses via neurochemical and metabolic pathways to improve bacterial resistance. These findings provide compelling evidence that targeting the neuroimmunological axis can be an effective strategy to minimize Salmonella persistence in poultry and improve food safety.

Key Words: gut, immunotolerance, prophylactics, neurochemicals, bacterial resistance.

     

Presented at the 9th Symposium on Gut Health in Production of Food Animals, St. Louis, USA, 2021. For information on the next edition, click here.

Related topics
Authors:
Melha Mellata
Iowa State University
Follow
Join to be able to comment.
Once you join Engormix, you will be able to participate in all content and forums.
* Required information
Would you like to discuss another topic? Create a new post to engage with experts in the community.
Create a post
Eduardo Lima
MCassab
16 de marzo de 2022
Hello, interesting approuch. Full paper available? Regards,
Siyanbola O.O
16 de marzo de 2022

I am interested in this approach as fecal bacterial shedding is the main reason for heavy burden of ever reoccurring reinfection challenge of poultry industry in Nigeria.

Join Engormix and be part of the largest agribusiness social network in the world.
LoginRegister