Dietary tributyrin, an HDAC inhibitor, promotes muscle growth through enhanced terminal differentiation of satellite cells

Published on: 07/25/2019
Author/s : Robert L. Murray 1, Wei Zhang 1, Marie Iwaniuk 1, Ester Grilli 2 & Chad H. Stahl 1. / 1 Department of Animal and Avian Sciences, University of Maryland-College Park, College Park, Maryland; 2 Department of Veterinary Medical Sciences, University of Bologna, Ozzano Emilia, Bologna, Italy.

Introduction Postnatal muscle growth and repair rely on the ability of satellite cells, muscle-resident stem cells, to activate, proliferate, and fuse into growing myofibers (Seale et al. 2000; Dumont et al. 2015). During the neonatal stage of life, the fractional rate of protein synthesis contributing to muscle growth is highest (Davis and Fiorotto 2009), marked by increased satellite cell activ...

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July 25, 2019

Dr. Chad, great article. With reference to their information, it can be deduced that the microbiota, due to the production of volatile fatty acids, including butyric, directly influences the health and development of pigs. Thus, it is evident that one of the desired characteristics in the strains of microorganisms that are used as probiotics is their ability to promote increased butyric acid production.

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Jon Bergstrom
Jon Bergstrom
Swine Nutrition & Production, Ph.D.
  Plano, Texas, United States
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