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A Longer Adaptation Period to a Functional Amino Acid-supplemented Diet Improves Growth Performance and Attenuates Acute-phase Response in Salmonella Typhimurium-challenged Pigs

Published on: 3/11/2021
Author/s : Lucas Rodrigues, PhD Student, University of Saskatchewan. Michael O. Wellington, PhD Candidate, University of Saskatchewan. J. Caroline González-Vega, Evonik Animal Nutrition. John K. Htoo,Evonik Animal Nutrition, Andrew G. Van Kessel, Professor and Head, University of Saskatchewan. Daniel A. Columbus, PhD, Research Scientist and Adjunct Professor, Prairie Swine Centre, Inc., Saskatchewan

Functional amino acid supplementation during disease challenge enhances growth performance and immune status. The present study investigated the effect of duration of adaptation period to a functional amino acid (FAA)-supplemented diet on growth performance and immune status during a subsequent Salmonella challenge in pigs. Thirty-two mixed-sex weanling pigs (8 pigs/treatment; 11.6 ± 0.34 kg initial body weight) received either a basal diet without FAA supplementation throughout the experimental period (FAA-) or a diet containing a supplemented FAA profile (Thr, Met, and Trp at 120% of requirements) fed for either 0 (FAA+0), 1 (FAA+1) or 2 (FAA+2) wk pre- and 1 wk post-inoculation with Salmonella Typhimurium (ST). Pigs were orally inoculated with saline containing ST after the 2 wk pre-inoculation period and monitored for 1 wk post-inoculation. Pigs had ad libitum access to diets throughout the experiment. Performance parameters [average daily gain (ADG), feed intake, and gain:feed (GF)] were measured in the pre- and post-inoculation periods. Blood samples were collected on d 0, 4, and 7 post-inoculation for serum haptoglobin and albumin analysis. There was no effect of diet on pre-inoculation performance (P > 0.05). Post-inoculation, FAA+2 pigs had the highest ADG (0.46 kg/d) and GF  (0.63 kg/kg), FAA- the lowest (0.21 kg/d; 0.29 kg/kg), with FAA+0 (0.33 kg/d; 0.46 kg/kg) and FAA+1 (0.40 kg/d; 0.53 kg/kg) being intermediate (ADG, P < 0.05, SEM=0.059; GF, P < 0.05, SEM=0.099). Overall, albumin was higher in FAA+2 (35.25 g/L) and FAA+1 (34.63 g/L) pigs compared to FAA+0 (30.38 g/L) and FAA- (29.67 g/L) pigs (P < 0.05, SEM=0.717). Furthermore, FAA+2 pigs had the lowest overall haptoglobin (0.90 g/L), FAA- the highest (1.54 g/L), with FAA+0 (1.32 g/L) and FAA+1 (1.06 g/L) being intermediate (P < 0.05, SEM=0.111). In conclusion, a longer adaptation period to FAA supplementation improved performance and attenuated the immune response of pigs when exposed to an enteric disease challenge.

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