Discussion created on 02/08/2011

Zinc to prevent mycotoxin effects

Forum: Zinc to prevent and treat mycotoxin effects

It has been found that the use of some Zinc preparation, when it is used in water and feed, has benefits in livestock, equines and goat health and production.

Dr. Karki Kedar
Doctor of Veterinary Medicine
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February 28, 2011

I do not see any direct evidence for this. Zinc boosts the immune system and helps in skin integrity. However, I would not consider as a potential and effective mycotoxin treatment.

Goupil Didier Goupil Didier
February 28, 2011

At which levels ?
We know that Zinc is an essential trace element , playing a role in many physiological functions , but can have a significant adverse effect on environment when in excess . We must use it at the usual required levels and not increase them ,even face to mycotoxins .

Anna Catharina Berge Anna Catharina Berge
PhD in Comparative Pathology
Berge Veterinary Consulting Berge Veterinary Consulting
Vollezele, Brabant, Belgium
February 28, 2011

I would strongly discourage the use of zinc for mycotoxicosis prevention. There are good mycotoxin binders on the market that bind a large array of mycotoxins. These have been scientifically assessed and proven efficacious in numerous studies. I would recommend a yeast-based mycotoxin binder such as Mycosorb (by Alltech) instead of clay binders, since clay binders are not as efficacious in binding a large variety of mycotoxins. There are environmental risks with zinc use.

Dr. Karki Kedar Dr. Karki Kedar
Doctor of Veterinary Medicine
March 1, 2011

Some salts of zinc act as antifungal, same way by oxidation process they cause inactivation of mycotoxin

Stephen Adejoro Dr Stephen Adejoro Dr
Doctor of Veterinary Medicine
March 11, 2011

Science is very dynamic and we need more scientific findings to counter the effect of mycotoxin on Bacteria resistances and vaccination failures.Nanotechnology experts have claimed that metals like cupper, Alluminiun amd Zink if shrinkedto nanometric level and integrated as cu++ ions ,zinc ++ions in clay , would act satisfactorilly as antibiotic growth promoters that will bind gram negative Ecoli and clostridia in poultry gut. It is obvious that some of the mycotoxin effects are resistance development, immune suppression and vaccination failures. I dont think we need to condem this findings but we need to encourage the inventor to educate us more on the machanism of action of the product. 

We need to understand that when matter are shrinked to nanometric level we alter their mode of action in such a way that they behave differently from their behaviour in the molecular stage. A Nanometre is10-9 of ametreor i/1000,000,000,of a metre that structure is beyonf the view of an electrom microscope. Nanotized products are more temperature tolerant and reactive that in the molecular stage.So it could be possible with modern technology to nanotize Zink and adapt it to prevent and treat mycotoxin effects. Acompany from France Olmix have made land slide success in this area of Nanotechnology for the effective management of toxins and their effects in livestock health and nutrition. With the ban on antibiotic growth promoters and the high degree of antibiotic resistances in the tropics new alternate products are highly welcomed

November 28, 2012

Zinc is an essential element many functions are recognized such as it is an essential part or a cofactor for a number of enzymes including carbonic anhydrase, carboxypeptidase, superoxide dismutase, lactate dehydrogenase, phosphatase and glutamate dehydrogenase (Prosser and Brown, 1966, Williams, 1969 and NRC, 1993). As a component of carbonic anhydrase, zinc playes a role in binding carbon dioxide in teleost cells, combining it with water to form carbonic acid and releasing carbon dioxide from capillaries at secondary lamellae of gills. Also, carbonic anhydrase is important in maintaining acid-base balance in renal tubule cells. As a cofactor of the protein-splitting enzyme carboxypeptidase, zinc has a key role in protein digestion (Sorensen, 1991). Fish accumulate zinc from both water and dietary sources; however, dietary zinc is more efficiently absorbed (Hardy et al., 1987). The zinc requirement of young rainbow trout and carp is 15 to 30 mg/kg of diet (Ogino and Yang, 1978 and 1979), wherease blue tilapia require 20 mg/kg of diet (McClain and Gatlin, 1988). Dietary protein source, phytic acid and form od zinc and calcium affect zinc absorption and use in fish (Hardy and Shearer, 1985, Wekell et al., 1986, Satoh et al., 1987 and 1989 and McClain and Gatlin, 1988). The bioavailability of zinc in fishmeal is inversely related to the tricalcium phosphate content. This is presumably caused by absorption of zinc into insoluble calcium phosphate complexes in the intestine that are passed through the gut unabsorbed and excreted (Satoh et al., 1987).

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