Discussion created on 01/22/2014

EFFECTS OF AFLATOXIN B1 AND PREPARATION «VITAKORM-BSR-FORTE» ON NO-SYNTHASE ACTIVITY IN RAT LEUKOCYTES

The effects of aflatoxin B1 (AFB1) and herbal preparation «Vitakorm-BSR-Forte» on
general activity of NO-synthases (NOS) in leukocytes of peripheral blood of white rats were
analysed. It was established that the development of experimental aflatoxicosis, provoked by
intraperitoneal administration of AFB1 (15 mkg/kg every day) lasting 14 days, was accompanied by
a significant decrease in NOS activity compared to control. Inhibition of NOS activity in blood cells
was accompanied by a decrease in nitrite content. The using of preparation «Vitakorm-BSR-Forte»
led to normalization of these indices in leukocytes. Our results demonstrate the effectiveness of
phytopreparation «Vitakorm-BSR-Forte» in reducing of metabolic abnormalities in animal blood
cells caused by aflatoxin B1.

Ch. M. Golovchak, H. L. Antonyak
halyna_antonyak@yahoo.com; ch_golovchak@inenbiol.com.ua, golovchak.kris@gmail.com

Golovchak Kristine
Biochemist
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