Aflatoxin M1 Residues in Milk and their Impact on Human Health

Published on: 01/21/2014
Author/s : Alberto Gimeno (Technical Consultant in Mycotoxins and Feed/Food Mycotoxicology for Special Nutrients Inc., USA)

Aflatoxins B1 and M1. Biotransformation  Aflatoxin B1 (AFB1) is a toxic secondary metabolite produced by several strains of Aspergillus, basically by Aspergillus flavus  and Aspergillus parasiticus. Aspergillus is considered an “storage fungi”: a temperature of 25OC and a water activity (wa) of 0.83-0.95 are ideal conditions for growth and mycotoxin production.  AFB1 c...

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Fernando Tamames Fernando Tamames
Executive
Special Nutrients Special Nutrients
Florida, United States
January 21, 2014

From the moment that the cow eats feed contaminated with Aflatoxin B1 how long it takes to be found as Aflatoxin M1 in milk?

Reply
ALBERTO GIMENO ALBERTO GIMENO
Chemical Engineer
January 21, 2014
Dear Fernando,

As indicated in the article, cows can transform aflatoxin B1 (AFB1) into aflatoxin M1 (AFM1) within 6 to 24h after consuming contaminated complete feedingstuffs with AFB1.

However, in some cases with aflatoxin B1 contamination in the complete feedingstuff of 5500 ppb, aflatoxin M1 was found in the milk within 3 to 6 hours after the consumption of AFB1.

Best regards

Gimeno
Reply
ALBERTO GIMENO ALBERTO GIMENO
Chemical Engineer
January 22, 2014

Dear Fernando,

Continuing with my answer, I tell you that, if we consider a consumption of 30 kg of the contaminated complete feedingstuff (over wet matter)/cow/day, with 400 ppb of aflatoxin B1 and an average milk production of 20 Lts, the milk contamination with aflatoxin M1 can be 10-13 ppb, within 6 to 24 h.

In the same feeding conditions and the same milk production, with a complete feedingstuff contaminated with 5500 ppb of aflatoxin B1, the milk contamination with aflatoxin M1 can be 160-180 ppb, within 3 to 6 h.

Best regards.

Gimeno

Reply
Fernando Tamames Fernando Tamames
Executive
Special Nutrients Special Nutrients
Florida, United States
January 27, 2014
If the transformation process is so fast then if you use a mycotoxin adsorbent how fast should it reduce the level of M1 in milk?
Reply
ALBERTO GIMENO ALBERTO GIMENO
Chemical Engineer
January 27, 2014

Dear Fernando,

These mycotoxin adsorbents (mixed with the feed), should be able in the gastrointestinal tract to form irreversible complexes with beta-cetolactone and alfa-bislactone groups of the AFB1 molecule. These non toxic complexes will be then eliminated in the feces.

In this case, the process to reduce or avoid a continuous milk contamination with aflatoxin M1 can takes 24-48 h.

Best regards

Gimeno

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Srdjan Nesic Srdjan Nesic
Animal Nutritionist
April 16, 2014
How about the other toxins, for example zearalenone? Is any data that you have about the excretion of ZEA into milk? How many hours after cows being fed with feed naturally contaminated with ZEA, can we detected metabolites into milk? Regards, Srdjan
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April 6, 2019
Srdjan Nesic my dear my work about zearalenone concentration in milk .no detected in milk after administration of zon 1000 micrograms daily in dairy goats for 14 days
With my regard
Dr.Adil
Reply
ALBERTO GIMENO ALBERTO GIMENO
Chemical Engineer
April 28, 2014
Dear Mr. Srdjan Nesic,
I know that my father would be very pleased to answer you and to give you assistance. Nevertheless, I am very sad to inform you that my father is not able to answer you, because he is no longer among us.
Carla Barreto
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