February 14, 2020
Another addition to the early written
In your article, all conclusions are correct, but they are associated only with the described study. This is an in-depth control of the contamination of raw materials with mycotoxins. This is a routine, albeit necessary work. She did not lead to new scientific conclusions. There are many similar works. The publications of the last decade differ from those that were 20-30 years ago in that more advanced analytical methods are applied and, in general, the previous conclusions are confirmed. You can conduct another 1- or 100 such studies, but how will they advance your (our) knowledge? What is the promising goal of these studies? I repeat: I look at them as an analytical work to control the contamination of raw materials with mycotoxins. I have no to give you advice, but during that time and the resources that you used you could find a lot of interesting things.
For example: A lot of work on the effect of individual mycotoxins on animals. Minimum permissible levels of mycotoxins in feed have been established, below which feed is considered safe. But how to evaluate the effect of several mycotoxins if they are simultaneously present in the feed and the concentration of each is lower than MPL?
I started work in this direction and one article was published in Russian. Below I propose a fragment from an article published in Russian magazines:
“ In practical conditions in feed there can be some MT at the different concentration capable to cause polymycotoxicosis. So, as a result of the analysis in compound feeds for broilers some mycotoxins were revealed: concentration of each of them didn't exceed MPL (tab. 1).
The assessment of compound feeds for broilers on the mycotoxins content.
mg/kg Complete feeds
Starter, mg/kg Grower, mg/kg Starter Grower ?PL, mg/kg
Aflatoxin ?1 0, 02 0, 005 0, 8 0, 20 0,025
Desoxynivalenol (DON) 0,40 0,540 0,4 0,54 1,00
?-2 toxin 0,04 0,042 0,4 0,42 0,10
Ochratoxin A 0,004 0,004 0,4 0,40 0,01
Fumonizin 1,00 3,500 0,2 0,70 5,00
In total 1,464 4,091 2.20 2,26
On the base of the current legislation, the above presented feeds can be fed without restrictions, so concentration of each MT is lower than MPL. The conclusion is not indisputable, but there are no other bases for the conclusion. On the estimation of parts value MPL it is possible to calculate the significance of each MT in parts of MPL which can be summarized, whether to estimate opportunities of the organism protection system. The sum of mycotoxins concentration in Starter consists 1,464, and in Grower - 4,091 mg/kg: a difference is 2,8 times. The increase in the sum of toxins in Grower is caused by the increased fumonizin content, but it remained lower than MPL. Summation of mycotoxins amounts in feed doesn't give the grounds for its objective assessment. However on the sum parts of MPL toxicity of feeds occurred identical and more than twice exceeded MPL. It means that it is impossible to call such feeds as a good-quality one.”
For Cite: Kryukov.V.S. Assessment of the level of mycotoxin contamination of feeds and efficacy of adsorbents/ Problemy biologii productivnykh zhivotnykh - Problems of Productive Animal Biology, 2014, 3: 37-50
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I understand very well that this method does not take into account the interaction of toxins. But you need to start with something. This is the first step and other researchers will criticize or develop this direction. But this publication will not leave indifferent.
I wish you all success
Prof. V.S. Kryukov