Special Nutrients Mycotoxin binder

Forum: Special Nutrients Mycotoxin binder product approved in Brazil

Published on: 05/16/2011
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May 16, 2011

I have no doubt that Mycoad can bind aflatoxins and reduct the amount of M1 being transferred into milk. However, just because it is the first to be approved by LAMIC for use in Brazil does not mean it is the only binder capable of reducing the transfer of M1 to milk. A number of researchers have shown that some binders are very good for this while others are not good aflatoxin binders (Stroud et. al. Dietary Additives to Reduce Aflatoxin Transmission to Milk of Dairy Cows. J. Stroud, E. English, S. Davidson, B.A. Hopkins, G. Latimer, W.M. Hagler, Jr. , C. Brownie and L.W. Whitlow, J. Dairy Sci. Vol. 84 Supp. 1, pg 129.)

The opening comment is a bit misleading. I know of no data that even suggests that aflatoxins are detodified in the rumen. Aflatoxins are absorbed across the rumen wall, transported by the bolld to the liver. Here in the liver, aflatoxins are metabolized in to still toxic metabolites such as AFM1, which, with high enough levels in the blood, appears as AFM1 in milk.

The only mycotoxins detoxified to any degree in the rumen are the trichothecenes (DON, T-2, etc.) but not aflatoxins.

Reply
Anna Catharina Berge Anna Catharina Berge
PhD in Comparative Pathology
Berge Veterinary Consulting Berge Veterinary Consulting
Vollezele, Brabant, Belgium
May 16, 2011

The rumens ability to bind mycotoxins have many times been overemphasized, and probably are not totally correct in the very high producing cow with high rumenal content turn-over. I wrote a recent short article on the topic: 

https://en.engormix.com/MA-mycotoxins/articles/penicillium-moulds-silage-how-t1662/p0.htm

Catharina

Reply
May 17, 2011
Another mine clay product in the market-HSCAS. However COLE value is to be declared to determine its superiority over others.
Reply
Fernando Tamames Fernando Tamames
Executive
Special Nutrients Special Nutrients
Miami, Florida, United States
May 23, 2011

As you well indicate there are other Anti-Mycotoxin Additives (AMA) that can adsorb Aflatoxin B1 BUT:
1) Mycoad is the first to be approved by LAMIC for Aflatoxin M1.
2) Critical in proving the effectiveness of an AMA is:
a) Dosage used
b) Level of Aflatoxin.
I have seen experiments that even SAND at 30 Kg with only 5 ppb of Aflatoxin is adsorbing 95%.
3) With Mycoad the scientific dosage is the same as the commercial dosage 2.5 kg /Mt which is one of the things that makes it unique when compared to other clays/AMA. Also all in vitro and In vivo test are done with high levels of aflatoxin 500 ppb, 5000 ppb and 7500 ppb.
4) Your comment “that some binders are very good for this while others are not good aflatoxin binders” should go even further. There are AMA that work in one species and do not work in others species. Most consumers are not aware of this fact.
5) Mycoad until now is the ONLY product approved by LAMIC for the control of Aflatoxin B1 in Poultry, Swine and Dairy. In the case of Poultry and Swine the approvals are based on Target Organ Protection (TOP) and for Dairy with Biomarker (Aflatoxin M1.)
6) Clays are like human beings there are no two alike. In fact the myth created in the 20th century that clays can only adsorb aflatoxin is just that, a myth. In the 21st century scientific trials have proven that some clays are not only capable of adsorbing Aflatoxin but also other mycotoxins. Recently companies that used in their marketing this myth for more than 15 years to make the point for the need of other components to control the other mycotoxins finally recognized in March 2009 that clays can adsorb other mycotoxins such as Fumonisin and Ergot alkaloids.
7) We always have indicated that there is not a single clay/AMA good for all mycotoxins. Also that some clays are good for some type of mycotoxins and that other clays are good for other types mycotoxins. The key of any AMA is clay, this is why until now there is not a single AMA that does not contain clay.
8) Mycoad is not only approved by LAMIC for the control of Aflatoxin in poultry but also for Fumonisin in poultry. Also Mycoad has scientific papers in Poultry Science against T-2 toxin and Ochratoxin with TOP results.
9) Mycoad AZ is approved by LAMIC for the control of Zearalenone and Fumonisin in swine. Also Mycoad AZ has scientific papers in Poultry Science against T-2 and in Animal science against Zearalenone, Fumonisin and Vomitoxin in Swine all with TOP results. Mycoad AZ was the first product in the world (November 2009 at EuroTier and March 2010 in Pig Topic) that presented the first information that clays can also adsorb Endotoxins. After our discovery subsequently other products have made the same claim.
10) I agree with you that the language of the first paragraph you could arrive to your conclusion by adding the following two phrases it should eliminate this problem:
………transformation into innocuous products. Part of Aflatoxin B1 it is biotransformed in the rumen by the action of the ruminal fluid into Aflatoxicol, that it is aproximatelly 10 times less toxic. Another part of Aflatoxin B1 is metabolized by the liver becoming Aflatoxin M1 that it is more toxic than B1. As a result, many ……… 11) I do not agree in your comment that “I know of no data that even suggests that Aflatoxin are detoxified in the rumen”. Even your colleges agree that Aflatoxin B1 can be degraded / bioconversion / biotransformed in the rumen when they presented the information during VIV Thailand 2009.

Reply
Zahar Gorbenko Zahar Gorbenko
Research
October 25, 2012
1) Why some binders work in one species and do not work in others species? Hawe anyone studied this question?
Reply
Fernando Tamames Fernando Tamames
Executive
Special Nutrients Special Nutrients
Miami, Florida, United States
October 25, 2012

As far as I know nobody has a scientific explenation

The theory behind this is that the GI track in each animal varies in:
Organs that go thruogh
Time period
pH variations

The fact is that LAMIC in Brazil when testic mycotoxin binders in different speicies they have seen that products work in one and do not work in another.

This similar puzzle applies to In vitro VS in vivo testeng.

LAMIC and many other universities have found that products hava a very good adsorption in Vitro 70% efficay in vitro it has worked in Vivo

This is the key reason for any mycotoxin binder to be able to make this claim it must have Statistical significance results ( not %) in Target Organ Protection (TOP) or contol of a biomarker (Afaltoxin M1 in milk sphingolipids in blood etc).

If a product only has data on imporving FCR or DGW or titers or white blood cells or red blood cells or improvemt of the immune system this is NO prove to make the claim to be a mycotoxin binder since this parameters can be affected by many types of feed aditives (antibiotics, yeast, enzymes ,acidifiers, hepatoprotectors, etc).

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