A study was conducted in selected areas of Khyber Pakhtunkhwa Pakistan, namely northern, central and southern region with the objective to determine
pathogenesis of contagious Caprine pleuropneumonia in field out break. A total of 120 goats were examined exhibiting clinical signs of pneumonia suspected for CCPP during disease out break. Animals in serious illness conditions were purchased, sacrificed and lesions in different visceral organs were recorded. On necropsy, samples were collected from the organs including lungs, trachea, heart, liver, spleen, kidneys and intestine were processed for histopathological examination. The predominant clinical findings includes pyrexia, nasal discharges catarrhal initially turned into mucopurulent in advance stage, excessive lacremation, unilateral / bilateral conjunctivitis with corneal opacity, painful cough, dysponia, weakness, reluctant movement, extended neck, abduction of elbow and diarrhea. Arthritis was not observed in any animals in the study area. Majority of animals presented pathological lesion in the form of consolidation and marbled appearance of lungs with fibrinopurulent membrane on pleural surface. Straw color pleural fluid was present in pleural cavity with pleural adhesion, hydro
pericardial fluid in pericardial sac, necrotic foci on surface of liver and pus in pelvis of kidneys. Histopathological lesions revealed emphysema, atelactasis with interstitial and bronchopneumonia and thickening of interlobular septa with extensive infiltration of polymorph nucleated cells. It was concluded that CCPP is widespread disease in all the three region of Khyber Pakhtunkhwa.
Keywords: Contagious Caprine pleuropneumonia, growth inhibition test, Mycoplasma mycoides Capri