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Biomarkers for mycotoxin exposure in livestock – A unique new service

Date of publication : 10/8/2019
Company : Innovad
Source : Innovad

Mycotoxins impair animal health, welfare and performance. These toxins are difficult to monitor and tools assessing both the risk in feed and the exposure impact in animals can contribute greatly in helping the producer to take the right measures and thus, avoid significant economic losses.

A 4-year PhD research project with the University of Ghent (Belgium) on the use of biomarkers for mycotoxin exposure in livestock has come to an end. This research, conducted by Dr. Marianne Lauwers and sponsored by Innovad, has yielded three scientific publications in the highly ranked journal of ‘Toxins’ (Impact Factor 3,273).

The first paper involved the necessary Method Development and the validation of the appropriate ‘Mycotoxin biomarkers for exposure’ in several biological fluids (blood plasma, urine, faeces and excreta) in pigs and chickens. The aim of this is to select which mycotoxins and (Phase I and Phase II) metabolites should be targeted and detected (i.e. bio-monitored) for a specific animal species and a specific biological sample, as this relates directly to their unique metabolism for each animal species and each route of dissemination in vivo.

The second paper proved the in vivo efficacy of Escent® S, Innovad’s unique platform for stress and mycotoxin control, as a detoxifier:

Namely, Escent® S is the only technology in the market that has shown so far:

  • Effect on animal detoxification. Namely, systemic reduction of mycotoxins in blood, urine and faeces (or bird excreta).
  • 50% reduction for DON (Deoxynivalenol) in chicken blood,
  • 40% reduction for AFB1 (Aflatoxin B1) in chicken blood, while the animals were contaminated with a blend of three mycotoxins (DON, OTA and AFB1) with the levels of OTA being 25x higher and AFB1 1,000x higher than the EFSA guidelines.

The findings are of great importance taking into account the direct toxicity of DON (and other mycotoxins) and their predisposing role in Necrotic Enteritis in chickens as well as a variety of diseases in different animal species.

Similar trends were found in pigs indicating thus, beneficial bioactivity.

The third paper refers to a successful transfer of the Analytical Methodology from (liquid) blood plasma to dried blood spots. In this case, only a drop of blood is collected on a filter paper. This has great advantages including: the sampling itself, reduced animal invasiveness, transportation without borders restrictions and increased storage at room temperature.

As future perspective, Innovad is now in collaboration with the University of Ghent to translate this into a UNIQUE SERVICE for its CLIENTS that opens for the first time the possibility of measuring with high sensitivity in real field conditions the true impact of Escent® S in animals. This sets Innovad at the forefront of this complex field .

In conclusion, the new lab service adds tremendously to the Escent® S platform, a truly unique platform for comprehensive control of toxin related stress:

  • Escent®S – more than just a toxin binder
  • Escent®S – four (4) modes of action: anti-oxidative stress, helping the liver, restoring natural immunity, binding polar (water soluble) toxins. Each mode is backed with field data
  • Escent® S – Full service of Risk Analysis in Feed and NOW, with an easy way in Blood by LC-MS/MS so that the true impact of Escent® S in animals is measured
  • Escent® L – Liquid intervention available as Escent® L in drinking water for short term application
  • Escent® S – Unique research with biomarkers in animals (chickens and pigs)
 
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