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Greener alternative to synthetic choline - KOLIN PLUS

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October 24, 2018
Dear Sir
You mentioned that syntetic cholin chloride is absorbed only 1/3 parts.could be fermented in ceca rest of SCC ?
Are there any role of SCC on the eggs taste like fishy taste ?
Best regards
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Miguel A Pérez Miguel A Pérez
Gerente de Comercio Exterior
October 24, 2018
BAYRAM KOC

Some clarification. I do not work for Natural Remedies.

Yes, Synthetic Cholin Chloride is absorbed only in 1/3 parts. Around 1 gram og Choline Chloride is equivalent to 44,75 mg de Choline. Some studies says that 60% of S.C.C. is coverted into TMA in the liver.

Best Regards,
Miguel from AdiNature, SPAIN.
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Dr Pooja Bhardwaj Dr Pooja Bhardwaj
Product Manager, Natural Remedies Pvt Ltd
Natural Remedies Pvt. Ltd Natural Remedies Pvt. Ltd
Karnataka, India
December 6, 2018
BAYRAM KOC We really appreciate your questions. Exact degradation process of CC in side the body is unknown but definitely releases the TMA which validate CC degradation.

Yes if uses the CC at high amount then fishy smell in eggs is very prominent.

Hope we reply satisfy you.
Reply
Mohit Agarwal Mohit Agarwal
Head Of Sales Marketing - Poultry at Ayurvet Limited
Ayurvet Limited Ayurvet Limited
Delhi, India
October 24, 2018
Hello Product Manager,

In your video you have suggested that 1/3rd of active choline is absorbed by the body where as since it is water soluble in my opinion 100% should be absorbable. If you are having some study please share.

Thanks,
Reply
Miguel A Pérez Miguel A Pérez
Gerente de Comercio Exterior
October 24, 2018
Mohit Agarwal

You are wrong. Only 1/3 of the Choline Chloride is absorbed as Choline, rest is converted in TMA (Trimethylamine) and other components.

There are many studies that talks about it, also, keep in mind one things: The main raw materials used to produce Choline Chloride are Trimethylamine, hydrochloric acid and Ethylene Oxide.

By the way, I do not have any partnership or business relationship with Natural Remedies.

Regards,
Miguel
ADINATURE, SPAIN.
Reply
Dr Pooja Bhardwaj Dr Pooja Bhardwaj
Product Manager, Natural Remedies Pvt Ltd
Natural Remedies Pvt. Ltd Natural Remedies Pvt. Ltd
Karnataka, India
December 6, 2018

Mohit Agarwal Good Question Mr. Mohit, And thanks for giving us an opportunity to answer it (especially to the hard core pharmacologist like me).

According to various pharmacological experiments, when a substance is administered intravenously, its bioavailability is 100% but bioavailability of any substance cannot be 100% through oral route (irrespective of its 100% water solubility) due to incomplete absorption (various reason, please refer pharmacodynamics book) and first-pass metabolism.
Dietary choline is absorbed from the lumen of the small intestine. The bioavailability of dietary choline depends on intestinal absorption: it is absorbed via mediated transport from the lumen of the duodenum, jejunum, and ileum. Before choline can be absorbed from the gut, some is metabolized by bacteria to form TMA. In fact, a significant fraction of ingested choline is destroyed by enzymes within gut bacteria, forming trimethylamine (TMA), dimethylamine (DMA) and monomethylamine (MMA). Some of these methylamines are eventually excreted into the urine. Therefore, it is evident that only 1/3rd of choline is available in blood stream.

There are two references for better understanding.
(Buchman AL, Jenden DJ, Moukarzel AA, Roch M, Rice KM, Chang AS, Ament ME (1994). Choline pharmacokinetics during intermittent intravenous choline infusion in human subjects. Clin Pharmacol Ther 55, 277-283.)
(Politzer Shronts E (1997). Essential nature of choline with implications for total parenteral nutrition. J. Am. Dietetic Assoc. 97, 639 - 646.)

Hope we have satisfied you by above information.

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December 8, 2018
Nice
Reply
December 11, 2018

Cost per ton is cheaper than synthetics cc?
And I concern about palatability.

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