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Feed Additives Market in the Middle East: CIBENZA® DP100 Enzyme Feed Additive and MINTREX® Trace Minerals

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Luciano Andriguetto Luciano Andriguetto
Owner of Ithaca Feed Solutions, Professor of Animal Nutrition at UFPr
May 9, 2018
Dear All,

I would like to add a few comments. If we look at ruminant nutrition, it is very common to analyse NFDN or NIDA, referring to protein associated with cell wall. I understand this explains why proteases yield better results when associated with NSP enzymes, and even phytase. I also understand that the association of proteases is always better than one single protease, as we will have endo and exoprotease activity, and specificity for different aminoacids, besides the pH range. It is worth mentioning that even as we classify enzymes as acidic or neutral or alkaline, it does not mean exclusive activity, rather maximum activity, as all enzymes have highest acitvity at preferred pH, decreasing slowly as pH moves away from optimum. So having all three enzymes is an assurance that we will see activity, regardless of diet composition, buffering capacity (which is higher in high protein diets), presence of organic acids or butyrate, limestone, different sources of phosphorus, micotoxin binders, etc. Proteases are also very useful for animals origin protein ingredientes, as we all know that the biggest problem in using these materials is their variability in composition and digestibility, and again, having more than one protease will provide a better result than a single one. And as was mentioned before, nowadays, with the prohibition on the use of antibiotics, avoiding undigested protein at the end of the digestive tract is an important means of preventing the growth of Clostridium, which is a proteolytic bacteria, fermenting and growing preferably on protein than carbohidrates. Finally, I would just like to add that, in my opinion, one big advantage of having a multienzyme complex, with NSP enzymes, proteases and phytase is an excellent way to handle one single matrix, removing the guessing from trying to bring different matrixes together, besides the safety in the mixing plant. And last but not least, always, when working with enzymes, we must remember that all benefits really depend on the ingredients. So it is of utmost importance that the nutritionist understand the products s/he is working with, both enzymes and ingredients, and figure for him or herself how to best apply the suggested matrix. As a nutritionist, I personally prefer to consider an amount of nutrients out of an enzyme product enough to pay for it, with a little margin, and leave the rest of the suggested matrix for the animals to show in the field, as better performance!
May 10, 2018
Luciano Andriguetto Dear Luciano, absolutely agree with you! Many different martix values in a single feed receipt is unreasonable. My firm have experience of one matrix values table for a enzyme blend containing 6 different enzymes activities. Question is that such matrix not easy to develop, necessary to perform a lot of laboratory tests in vitro, and than follow in vivo. Buy it is really correct way to reach high result.
Kamaran Abbas Kamaran Abbas
May 11, 2018

Dr. Fiodor S. Marchenkov , I agree with you. I used multi enzymes in broiler diet with certified origen, has good results. when we used other origen multi enzymes the same results was not found. This indicates the differences in results obtained from other friends who discussed the issue above.

dan hofer dan hofer
Poultry farmer
May 15, 2018
have any of u ever tried feeding alfalfa got some good nutrient values
May 16, 2018
Enzymes are specific to substrarte.

Cocktail enzymes have good results.
Rider Anderson Perez Maldonado Rider Anderson Perez Maldonado
Technical Manager at DSM Asia Pacific
May 18, 2018
Dear All Certainly I would agree with Dr Cowieson comments due to clarity on explaining mode of action of Phytases and Proteases working together (even with carbohydrase present in the diet) for improving livestock performance. Emphasis should be made that Phytases mode of action on AA digestibility is link with the reduction on endogenous AAs loses whereas a good protease main mode of action is on dietary protein solubility and digestibility improving AA digestibility. Data from Vieria et al (2016) on the combination phytase + Protease work showed a significantly improvement on BW, FCR, tibia P, and ileal digestibility on DM CP and IDE. This was achieved just by adding 200 ppm protease on top of a diet containg double phytase dose. The take home message is that a right Protease combined with phytase and other enzymes works. Data has shown that a right protease can improve at least 10% phytic acid solubility and animal performance by 1-3%. More recently (2017) results in Australia indicated among other beneficial effect on performance net energy improvement calculated at 4%.
Mirza M H Mushtaq Mirza M H Mushtaq
PostDoc in Poultry Nutrition
May 18, 2018
Question is that how to merge two matrices, phytase + protease or even with carbohydrases when individual enzyme sources are used? Practicality of this merger would also be according to diet either vegetable or animal base ingredients. So complex situation.
Rachel Zchang Rachel Zchang
Marketing Manager
May 21, 2018

Are there anyone can help explain why when we add high dosage of neutral protease to a CP&AA reduced 4% down diet compare with the PC and NC (CP&AA reduced 4% down diet), but the protease added groups are even worse than the NC Group on the weight, feed intake and weight gain, similar FCR, and worse EPI.

Will too much protease bad to the animals?

Mangalmurti Pathak Mangalmurti Pathak
MVSc & A.H. Animal Nutrition
May 22, 2018

The effect is more significant in pellet feed compared to mash feed due to fact that protein digestibility in proventriculus is poor in pellet feed compared to mash. Undigested protein act as good media for the growth of pathogenic organisms.

May 30, 2018

Dear All, I would like to enjoy this important forum to talk about this subject, especially in this moment that We have serious problems regarding the cost of raw materials in the Latin American market. We believe in a beneficial effects of xylanase, protease and phytase especially in superdosing levels, when We talk about the amino acid levels. Some limitation is likely not related to the lack of efficacy of any one of the individual enzymes but to a limitation of the animal to respond additively to successive additions of enzymes. This situation raises an important question: Which enzyme should We choose? To help answer this question, we published a review in 2017.

In this text, we present clearly that all enzyme inclusions had some beneficial effects on at least one parameter during bird development, but a lack of any additive response, with further improvements when all enzymes were used together, shows that enzyme response may be limited not by a substrate limitation, but by the inability of the animal to further improve performance. In this way, we always suggest that the cost of diet and the ROI like most important topics which must be considered in the choice of maximum 2 enzymes for mineral, energy and especially amino acids matrices!

August 8, 2018

Good morning,
Can we have a brief about the stability during pelleting?

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