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Agranco Corp. - United States
MAST-EXMastitis TREATMENT via feed - with a Unique Micro-Encapuslated Technology MOST PROBABLE CAUSE(S) OF MASTITIS Thus far, the most common causes of mastitis in dairy animals have been primarily imputed to the infectious agents (Zhao and Lacasse 2007). On the basis of infectious causes of mastitis a procession of drugs purported to be effective against these culprits emerged on the scene for controlling this ailment in dairy animals. In the beginning these drugs appeared specious. However, continual use of these chemicals proved palliative and confronted with biggest problem of drug resistance and milk and meat residue dangers for humans (Costa and others 1997). Moreover, the effectiveness of these antimicrobials was rarely more than 50% to control mastitis in dairy animals (Deluyker and others 2005). Different management practices e.g., dry-cow therapy, teat dipping, hygienic measures etc., were evolved to alleviate effects of this formidable problem, but the devil of mastitis is still starring and unrelenting. Nevertheless, delving disparately into the milk synthesis the mechanisms of injury to the parenchymatous tissue of the udder appears to becoming a bit clearer. It has been widely demonstrated that citrate is the “harbinger of lactogenesis” (Peaker and Linzel 1975). They further reported that the level of citrate in udder of cow, goat and women shoots up 46 times around parturition. These findings enthuse one to speculate that citrate is apparently playing a pivotal role in milk synthesis and might be associated with mastitis in dairy animals. It has been reported extensively that mastitic milk is significantly low in citrate (Oshima and Fuse 1981). Our investigations have also revealed that citrate levels are very low in milk of quarters affected with mastitis (33.71mg/ 100ml). A certain minimum concentration of citrate is essential for the normal synthesis of milk in the alveoli in the udder. Therefore, any in the citrate content would result in faulty synthesis of milk in a particular quarter(s) of the udder. We have observed that the affected quarters had very low concentration of citrate as compared with healthy quarters of the same animal (Dhillon and others 1989). The deficiency of citrate in a particular quarter may be due to nutritional, metabolic or some other intrinsic unknown factors which need further investigation.Citrate, indeed, is the main constituent of the buffer system responsible for the maintenance of pH (~6.50) in the udder and regulates the homeostasis between Ca2+ and H+ ions and is the mainstay for the fluidity of milk through its effect on casein micelles (Faulkner and Peaker, 1982; Shennan and Peaker 2000). Citrate in udder also ensures the sequestration of soluble Ca2+ in milk (Kon and Cowie, 1961) and there is significant synchronization between the two (Holt and Muir, 1979). Hence, deficiency of citrate in udder would lead to the “clumping” of Ca2+ which manifest as flakes in the mastitic milk. These flakes of Ca2+ behave like lime and probably injure the parenchymatous tissue in the udder alveoli due to reduced moderator effect of citrate. Following this injury the impermeable barriers to citrate in both directions between blood and milk is disrupted and the inflammatory reaction sets in leading to an array of subsequent events. Such injuries due to free Ca2+ has been reported in myocardium (Fleckenstein and others 1974 ; Singal and others 1979). It has also been recorded that a calcium-dependant endonuclease is associated with necrotic type changes in tissues (Arends and others 1990). Furthermore, important ions e.g., bicarbonate, chloride, sodium etc., transudates from blood into milk during mastitis due to permeability of tight blood-milk barriers. Thus, swapping of ions between blood and milk brings the pH of milk equal to that of blood or even higher and changes the pH of udder towards alkalinity i.e., 7.4 or higher. The lesions inflicted by free Ca+2 and most conducive alkaline milius in the udder prompts the environmental pathogens (commensals in the udder?) to invade and establish clinical/subclinical “infectious mastitis”. Consequently pathogenesis is further exacerbated with the involvement of body defense mechanisms and severe inflammatory reaction ensues (Zhao and Lacasse 2007). Control and Treatment of MastitisMastitis is a perpetual problem of all milk producing animals. The conservative estimates of economic losses from this malady have been made almost in each and every state world-wide. Several groups of scientists are working disparately to find out the exact cause and effective treatment of this most formidable disease. Though much of the work on intricate biochemical interactions at the molecular level directed towards unveiling the nub of this malady are being elucidated but still the problem appears elusive.Coming down to the versatile dairy animal, buffalo (Bubalis bubalis), the “Asian Black Gold” a population of about 130 million globally suffer extensively from mastitis (Fagiolo and Lai 2007). Despite the use of best available facilities at hand to understand the pathobiology of mastitis, the problem still remain economically most important to the dairy industry throughout the world. The ideal modus operandi to prevent or reduce the economic losses, the definite cause of mastitis must be identified and then possible control measures implemented. While scanning the literature on mastitis and biosynthesis of milk in the udder it became apparent that citrate plays a very crucial role in the lactogenesis and maintenance of udder health through ionic equilibration (Peaker and Linzel 1975, Hyvonen and others 2010). Citrate level is always low and concomitant pH high in mastitic milk (Dhillon and others 1989). It was hypothesized that replenishment of citrate deficiency with extraneous tri-sodium citrate might play some protective role against mastitis, hence, these studies were undertaken and the results are communicated in this paper. Author : K. S. Dhillon, Ph.D and Jasmer Singh, Ph.D (College of Veterinary Science GADVASU) PRESENT STANDARD TREATMENTTreatment of mastitis with this salt has been standardized by enhanced doses to cut-short the recovery period (Dhillon and others 2007). The oral dose has been raised to 30gm in 250ml of water daily as a drench and recovery period cut-short to 3-5 days depending upon the severity of mastitis (Singh and others 2007). The disruption of the impermeable barrier between blood and milk in udder, as stated above, formed the basis of intravenous administration of tri-Sodium citrate. The dosage of this salt was standardized in cow-calves. Intravenous administration of medication directly reaches at the site of injury and normalizes the pH (~6.5) in the udder and the infectious agents are scavenged off and restoring ionic equilibrium. Moreover, the slightly acidic pH in normal udder is not suitable for generally isolated microbes from mastitic milk. With intravenous administration of tri-Sodium citrate in sterilized normal saline as 5% given morning and evening in 50ml doses the recovery period shortened to 1-3 days (Dhillon and Singh 2009, 2011). This treatment was safe, economical, very effective, avoided culling and discarding of milk with the minimal pain to the animal. Moreover, there is no withdrawal periods and hazards from residual problems in milk and meat. Presently, tri-Sodium citrate is employed extensively for the control of mastitis in dairy animals at farms with remarkable success. This treatment has also been found to be very effective in cases of mastitis refractory to antibiotics. On the basis of our investigations some pharmaceuticals have come-up with formulations intended for prevention and treatment of mastitis in dairy animals., Italy. 635 Mastitis is the most costly dairy cattle problem to the industry. As mastitis problems increase, profits decrease. Reduced milk production accounts for approximately 3/4 of the total loss associated with mastitis. Without an effective mastitis control as much as 40% of the cows can be affected. The legal limit of SCC in milk is 750,000 cells per ml of milk. My specialists indicated that management practices to reduce the SCC from 400,000 to 200,000 cells/ml of milk will increase milk production by 1.5 lbs/day. Given a 100 cow herd this can account for 150 lbs of milk per day loss. At today’s prices this amount of milk has a value of $24.75/day or $7,548/305 day milking for the reduction to 200,000 SCC. An estimated total loss of milk production with 400,000 SCC is 4.5 lb milk/day which is valued at $226 per cow per year or $22,600 per 100 cow dairy. Wayne Greene, Ph.D., PAS, Diplomate ACAS Professor and Head Department of Animal Sciences Auburn University EXAMPLE OF THE COST OF STANDARD MASTITIS TREATMENTSTreatment statistics per lactation. Lactations that utilized antibiotics in addition to supportive therapy incurred $21.35 more in average treatment costs than lactations utilizing supportive therapy alone. Although total cost was greater in antibiotic lactations, the duration of the clinical mastitis episode was shorter. Lactations that utilized the antibiotics along with supportive therapy also had lower severity scores than supportive therapy alone. Cows treated with supportive therapy alone lost 374 pounds more milk than cows treated with both antibiotics and supportive therapy, but cows treated with antibiotics along with supportive therapy had twice the amount of marketable milk over supportive therapy alone due to use of antibiotics and the associated withdrawal period. Although the addition of antibiotics to supportive therapy decreased the magnitude of milk loss, the total cost was $103 more per lactation than use of supportive therapy alone. MAST-EX:Is a micro-encapsulated form of enhanced trisodium citrate in a special matrix, administered as a feed additive for the prevention and treatment of MASTITIS, instead of the previously referred conventional treatment forms. The matrix protects the active ingredients as it passes through the animal rumen and start to release the active ingredient as it enters the small intestine. The release is gradual and distal and is caused by the natural enzymes produced by the animal. DOSAGE:MAST-EX is dosed daily at 50 grs. Per head per day. The period of adlinistration should be 60 days prior to calving and shpuld go 305 days post calving MAST-EX Physical Characteristic:MAST-EX is a free flow white powder with fruity smell and a particle size of 700 to 900 microns. BENEFITS:In addition to milk loss prevention, administering MAST-EX in the feed will make it unecessary to handle the animal daily to adminsiter injections and/or drinking liquid preparation for treating MASTITIS. MAST-EX Mode of Action 1. Microencapsulated slow released MAST-EX is released in the junction between the abomasum and small intestine and absorbed along the small intestine into the blood stream for transport to the mammary gland by milk arteries. 2. Once in the udder The MAST-EX compound is disassociated releasing its two major components into the milk cistern to help regulate the pH of the udder towards a pH of 6.5. At pH of 7 or higher the alkalinity of the udder is such which promote the growth of harmful mastitis pathogens such as Staphylococcus , Streptococci, E coli, Bacilli and Klebsiella. 3. A key component of MAST-EX maintains the pH of the milk at 6.5 which prevents the growth of mastitic organisms and thereby decreases the incidence of clinical and subclinical mastitis. Appearance: Powder, white free fllowing Is a micro-encapsulated form of enhanced trisodium citrate in a special matrix, administered as a feed additive for the prevention and treatment of MASTITIS, instead of the previously referred conventional treatment forms. References ARENDS, M. J., MORRIS, R.G. & WYLLIE, A. H. (1990). American Journal Pathology 136, 593BENITES, N. R., GUERRA, J. L., MELVILLE, P. A. & da Costa, E.O. (2002). Journal Veterinary Medicine B 49, 366BRAMLEY, A. J., GODINHO, K. S. & GRINDAL, R. J. (1981). Journal Dairy Research 48, 379 COSTA, E. O., GARINO, F., WATANABE Jr E. T., et al. (1997). Brazil. Proceedings 5th World Buffalo Congress, Caserta, Italy. 635CRUICKSHANK, R., DUGUID, J. P. & SWAIN, R. H. A. (1970). Medical Microbiology: A Guide to the Laboratory Diagnosis and Control of Infection. The English Language Book Society and E & S Livingstone ,pp 39,101.DELUYKER, L. A., VAN OYE, S. N. & BOUCHER, J. F. (2005). Journal Dairy Science 88, 604DHILLON , K. S. & SINGH, J. (2009). Veterinary Record, 8th August, in Letters......................&................ (2011). Proceedings 30th World Veterinary Association Conference, Cape Town, Oct, SINGH, S., VARINDRA & SINGH, T. J. (2000). Indian Journal Dairy Science 53, 32...................., SINGH, T. J., SODHI, S. S., SANDHU, H. S., DWIVEDI, P. N., SINGH, J. & GILL, B. S. (1995). Indian Journal Animal Science 65, 9....................,KUMAR, H., DHALIWAL, B. B. S., BAL, M. S., PANNU, M. S. & SINGH, J. (2007). PunjabVeterinary Journal 5, 55FAGIOLO, A. & LAI, O. (2007). Italian Journal Animal Science 6(Suppl, 2), 200FAULKNER, A. & PEAKER, M. (1982). Journal Dairy Research 49,159
A unique combination of natural extracts with liver stimulant and chemo-adsorption activities... The performance profitability in farm animals depends upon improved feed conversion efficiency, body weight, absence of diseases and low mortality for which the Liver plays and important role being a vital organ of the system responsible for important functions or hypoactive sluggish liver directly or indirectly affect vital functions and results in poor utilization of nutrients resulting in low productivity, frequent disease outbreaks and finally poor FCR. AGRABOND FUZION is a poly-modal formulation containing plant compounds, yeast extracts and modified clays. These synergistic actions by virtue of their multifaceted/poly-modal effects produce a Hepatogenerative, Hepatostimulation and finally an anti-hepatotoxic protection against xenobiotics / mycotoxins found in the feed and water. Click to enlarge image Triple Fuzion Effect: 1. Chemi-adsorption: Modified Mineral Blend 2. Yeast extract / Probiotics: Organic Binding-Immume Stimulation 3. Herbal Plant Extracts: Hepato - Protector / Re-Generation Detox Beneficial Effects: - Potent liver tonic & a Hepato-Protector from feed contaminants / toxins and antibacterials / antibiotics - Helps in rapid regeneration of the Liver Cell. - Improves feed utilization / metabolism, which increases FCR and overall performance. Recommended Dosage: Poultry: Pre - starter / starter diets: 350 grams per tonPigs: 500 grams per ton Aquaculture: Salmonoids: 500 grams per tonShrimps: 500 grams per tonTilapias: 500 grams per ton Ruminants:Dairy Cows: 15 grams per head x day. Agrabond - Fuzion represents the most innovative poly-modal intervention against actual outbreaks of micotoxicosis threatening the global feed industry. Agrabond – Fuzion deals with the problem in an integrated and synergistic manner. Agrabond- Fuzion possesses a multi-strategic / Poly- modal controls intended for micotoxicosis/xenobiotics through: 1. Enzymatic detoxification & biotransformation effect leading to loss of the toxicity of different mycotoxins found in the feed. 2. Reducing Mycotoxin absorption & bioavailability through its unique selective modified adsorptive capacity. 3. Microbial / fungal antagonism that significantly inhibits both growth of the mycotoxigenic fungi (spore vegetation) and reducing their Mycotoxin production. Includes in its composition a mix of complex carbohydrates, obtained from the cell walls of Saccharomyces cerevisiae; mannan oligo saccharides (MOS), Beta glucans (1-3 and 1-6 β-glucans), that stimulate the immune system; thus defending the animal from the immune suppression caused by the different mycotoxins/xenobiotics. The MOS and β-Glucans activate the GALT systems and block via macrophages entero- pathogenic bacteria like E. coli, and Salmonella in the digestive tract of the animal. 4. Reduction in Liver toxicity through the action of herbal extracts present in the product. Hepatoprotective / re-generation effect is produced mainly by the antioxidant and free- radical scavenging by the Phenolic- Flavonoid compounds, increasing the innate capacity of the animal to detoxify the toxins and promote elimination. Benefits: - Protects the animal against a wide range of mycotoxins /xenobiotics. - Increases bile flow from the liver to the spleen. - Improves the hepatic response of animals. - Improves the immune response of animals. - Increases the zoo technical productivity of the animal. - Reduces the presence of mycotoxins in meat, milk and eggs. - Improvement of the intestinal health. - Free of dioxins. - It does not have collateral effects and has a high safety profile that needs no withdrawal time. - It does not adsorb vitamins or other ingredients. - All the ingredients used in their manufacture are recognized as safe (GRAS) and approved by the Association of American Feed Control Officials (AAFCO).
A Concentrated Form of Refined Copper Micro-Encapsulated Organic Acids and Essential Oils What is AGRACOPPER? AGRACOPPER is a concentrated form of refined copper protected in a special matrix of fatty acids, for its utilization as an intestinal modulator in animal feeds. Mode of action AGRACOPPER’S Slowly and controlled release of the refined copper in the intestinal tract is for the improvement of intestinal health and for the effective reduction of scours in piglets. It also provides a combined synergistic effect with ZNO to reduce E.Coli diarrhea. Agracopper Since it is microencapsulated in a lipid matrix, palatibility problems are eliminated. More effective in the control of diarrhea by reducing the need for antibiotics and growth promoters. Its effect is complete along the entire small and large intestine. Antibacterial effect of Agracopper A high level of inclusion of Zn and Cu diminshes the activity of pathogens bacteria. (Ole Hojberg et al, 2005). Bivalent cations of Zn ion (Zn ++) and Cu (Cu ++) seem to have an affinity with the linking sites of E. coli. Zn ion and Cu, preferably link to glycoprotein and to glycolipid of the intestinal wall, which present negative charges. E. coli cannot find any union site to adhere, penetrate and generate toxicity in the tissue in question. For this purpose the zinc/cooper ion shall be easily released at the proper time and place. How Does Agracopper Work in the TGI? Antiviral Effect and Excessive Immune Response of Agracopper The Cell Adhesion Molecules (CAMs) are proteins located on the cell surface involved in the process of adhesion to other cells or the extracellular matrix in a process called "cell adhesion". Cu ions get to block the joints between the Virus and the cell membrane’s CAMs, thus reducing the infection of epithelial cells in the intestine. On the other hand, once the ions adhere to CAMs, they can also block the joints between them and the immune cells that cause inflammation, regulating the flow of these cells to the intestinal epithelium thus preventing allergies due to excessive immune responses. Agracopper Copper Sulphate - 70% Copper Sulphate Micro-Encapsulated Premix for Use in Animal Feed Composition For every 100gr. content: Active Material: Copper Sulphate 70% Coating Material: Hydrogenated Vegetable Oil Characteristics Agracopper is a micro encapsulated Copper Sulphate supplement. The micro encapsulation ensures a more effective release of copper in the gastro intestinal tract of the animal. Copper Sulphide, the principal component in Agracopper contributes to improved production performance and prevention of diarrhea in piglets. Mode of Action The lipids of vegetable origin that form the coating Agracopper are degraded by pancreatic lipase when the product reaches the duodenum. Subsequently the copper is slowly liberated in the small intestine. In this way, the distal part of the small intestine becomes the place for obtaining micro flora modulating effect. Agracopper Copper Sulphate - 70% Product Properties: Appearance: Granular, free flowing powder Color: Light Blue Odor: Characteristic, Slightly sweet fatty acid Physical Properties: Moisture: <3% Particle Size: Uss 20(850u) .05% Max Temperature of maximum 90-95 C° when coating is melting Additional Information Presentation: Polyethelene bags in 20kg boxes or 50kg drums. Storage: Store in dry place, ambient moderate temperatures, in closed packaging when product is not being utilized. Shelf Life: Best before 12 months from date of manufacturing. GMO: All the ingredients used in the manufacturing of Agracopper is Non-GMO Doses according to species Swine: Weaning piglets 25-80 g/MT of complete feed. Other pigs 300 g/MT Layers, Broilers, & Turkeys: 50-100 g/MT of complete feed. Dairy Cattle: 12g of Agracopper per head, per day. All ingredients approved by FDA under the American Association of Feed Control Officials under Official AAFCO N° 57.150. Publication: 1,998 Country of Origin The good actions of today make for a better tomorrow AGRANCO World Distribution Network Agranco Group is a manufacturing and sales organization headquartered in Coral Gables, Florida and manufacturing companies located in Mexico and the U.S. It has a network of distributors in Mexico, United States, Central America, South America, Europe, Middle East, Africa and Asia, all dedicated to providing distribution and service of our products, with its own staff of engineers, technical specialists and PhD in every area of activity. Animal Nutrition: Selective Adsorbents Mycotoxins, Organic Minerals microencapsulated probiotics and Immunomodulators, Enzymes, Yeast and Microflora regulators. Agricultural Industry: Organic Insecticides, Fertilizers, natural and biodegradable. Aquaculture Industry: Yeast, Enzymes, Probiotics and oligosaccharides for shrimp and fish rations. Food Processing: Disinfectants food for human consumption. Sugar Industry: Stabilizers of pure cane juice Water Treatment: Decomposers of organic matter and water purification. The products are marketed under its own brand, are unique and specific to improving processes in each industry, fully researched about them, proving their effectiveness in every field. We invite you to evaluate waiting to exceed your expectations and be part of our user list.
Agrazinc 100 - Zinc oxide for food
Microencapsulated Oxide For Poultry, Swine and Bovine Feeds TECHNICAL SUMMARY What is AGRAZINC 100? AGRAZINC 100 is a concentrated form of zinc oxide that has been micro-encapsulated for a more effective release into the gastrointestinal tract of animals. Mode of action AGRAZINC 100 has been micro-encapsulated with an edible lipid based matrix. This process masks the taste of Zinc Oxide and diminishes the possible inter-activity of ingredients while maintaining dissolution characteristics typical for most immediate release. AGRAZINC 100 releases zinc oxide when encountered with the corresponding adequate ph in the micro-areas of the gastro-intestinal tract. Rate of application SWINES, LAYERS, BROILERS AND TURKEYS: 100 grams per MT of feed. DAIRY AND BEEF CATTLE: 100 grams / 125 heads daily. HORSES: 800 mg. / head daily. SHEEP: 100 grams / 125 heads daily. AGRAZINC 100 Specifications ASSAY: 485 - 500 MG/G. PARTICLE SIZE: 60 US Std. Sieve - NMT 50% on screen Application Nutritional suplement Packaging and storage 20 kg poly-ethelene bags in export carton boxes. Store in dry area, under roof at ambient temperature. All ingredients approved by (FDA) under American Association of Feed Control Officials under Official (AAFCO) No. 57.150. Publication: 1,998.
Agrabond - Mycotoxin adsorbent
Selective Adsorbant of Fusarium and Aspergillus Mycotoxins for Poultry Breeders and layers, Swine and Bovine TECHNICAL SUMMARY What is AGRABOND? AGRABOND is a calcium and sodium based alimino-silicate carefully selected and treated with AGRANCO''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''S proprietary process, creating a very high affinity, tp specifically and effectively adsorb Fusarium and Aspergillus toxins, designed to be used in raw materials and finished feeds for all animal feeds. AGRABOND is certified by Romer Labs and Trilogy Analytical Laboratories in the United States, recognized specialists, in mycotoxin binding analysis, to be 97% and 100% effective, respectively, in adsorbing fusarium toxins. Romer Labs has certified AGRABOND to be 94% effective in aflatoxin adsorption. In multiple cases of mold problems in raw materials and finished feeds that show material free flow difficulties, after mold develops, its secundary metabolites, such as mycotoxins, among them, Fusarium toxins cause severe lesions in animals that eat the contaminated feed. Other fusarium mycotoxins cause immuno-supression in animals , as well as peak erosion and high mortality in borilers and weak eggs shells in layers. Field experience has shown that when feed is treated with AGRABOND it adsorbs selectively Mycotoxins associated with these symptoms, which disappear in the animals as a result of the presence of AGRABOND in the feed. It works in the gut of the animal by cationic exchange when mixed in the feed , freeing the feed from its harmful effects, and allowing the excretion of the Mycotoxin without permitting its absorption through the intestinal wall. AGRABOND''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''s unique 100% adsorption capacity is guaranteed by its ample surface activity, due to its special particle size (Dry 98% through 325 mesh and wet through 99.0% mesh). Chemical Analysis SiO2- 72.8 %, Al2o3 - 26.4%, Fe2O3 - 0.1%, k2O- 0.3% MgO- .1%, CaO- 0.2% Na2O-0.1% Physical Properties: · % Weight passing through mesh 325: 99.9 , Miosture : 2.0, Specific Gravity :1.6 , Particle size : 2.0 microns, Color : light grey, Form: Powder. Use Dossage Dosis per MT of feed: For all poultry feeds: 500 grams / MT Breeder and grower swine rations. Prophylactic: 500 grams per MT of feed. Lactation and Gestation: Dosis: 1 kg / MT. Certified 100% efficacy by TRILOGY ANALYTICAL LABORATORIES,INC. Certified 97.3 % efficacy by ROMER LABS , INC Certified 100 % efficacy by LAMIC ufsm.- Brasil Potency: AGRABOND is certified to be 94% to 100% effective at low incluision rates (500 grams / MT) against Fusarium and Aspergillus Mycotoxins, by Trilogy Labs and Romer Labs in the USA and by LAMIC in Brasil
Agrabond (afl) - Aflatoxins adsorbent
TECHNICAL SUMMARY What is AGRABOND (afl)? AGRABOND (afl) is a calcium and sodium based alimino-silicate carefully selected and treated with AGRANCO''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''S proprietary process, creating a very high affinity, tp specifically and effectively adsorb Aflatoxin. AGRABOND (afl) is designed to be used in raw materials and finished feeds for all animal feeds. AGRABOND (afl) is certified by Trilogy Analytical Laboratories in the United States, recognized specialists, in mycotoxin binding analysis, to be 100% effective in adsorbing Aflatoxin. In multiple cases of mold problems in raw materials and finished feeds, that show material free flow difficulties, after mold develops, its secundary metabolites, such as mycotoxins, among them, Aflatoxin, cause severe harm to the harm to the animals that eat the contaminated feed. When this affected feed is treated with AGRABOND (afl), it adsorb selectively Aflatoxin in a very effective manner by means of a cathionic interchange mechanism, freeing the feed from its harmful effects, and allowing the excretion of the Aflatoxin, without permitting its absorption through the intestinal wall. AGRABOND (afl) ''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''''s unique 100% adsorption capacity is guaranteed by its ample surface activity, due to its special particle size (Dry 98% through 325 mesh and wet through 99.0% mesh). Chemical Analysis SiO2- 63.3 %, Al2o3 - 21.4 %, Fe2O3 -3.8 %, k2O- 0.3% MgO- .2%, CaO- 0.7% Na2O- 2.7 % Physical Properties: % Weight passing through mesh 325: 99.9 , Moisture: 7.0 %, Specific Gravity: 2.5 , Particle size: 2.2 microns, Color: light gray, Form: Powder. Use Dossage Doses per MT of feed: Prophylactic 500 grams /TM .Treatment- 1 kg. / TM Aflatoxin adsorption efficacy: 93 % Increase in Potency: The efficacy of AGRABOND (afl) is increased exponentially if the feed contains our product Hydroenzyme. This is due to the hydrolytic effect of Hydroenzime , that expose a greater number of the Aflatoxin links with proteins, carbohydrate, fats and other nutrients, maximizing the AGRABOND (afl) adsorption capacity. PHYSICAL PROPERTIES: Specific Gravity 2.5 PH ( 6% ) 9.0 Moisture % 7.0 Cathionic interchange capacity- ME/100 G 105 Lipid compounds absorption- ASTM D 281-31, Lb/100Lb 41.0 Specific surface area 20 SQ M/GR Density 60.0 LB - PIE 3 LOI 12 CHEMICAL ANALYSIS Mineral Blend – Main component: Silicon Dioxide SiO2 63.3 Al2O3 21.4 Fe2O3 3.8 MgO 2.0 CaO 0.7 Na2O 2.7 K2O 0.3 USAGE INDICATIONS DOSIS- PROPHYLACTIC : 1 Kilo Per Mt of feed. DOSIS IN HIGH PRESENSENCE OF AFLATOXIN: 1 kg / MT
Agraculture Fermented metabolites for Livestock and Aquaculture. TECHNICAL SUMMARY WHAT IS “AGRACULTURE’? Probiotics are widely used to promote and improve animal health and growth performances in livestock animals and aquaculture around the world. Among these beneficial bacteria, AGRACULTURE is related with “YEAST” (Saccharomyces Cerevisiae). AGRACULTURE is “the yeast-fermented metabolites concentrate” to supply various nutritional factors. AGRACULTURE is precisely a concentrate of yeast fermented metabolites. “AGRACULTURE” METHOD OF MANUFCATURE: AGRACULTURE was developed for livestock animals and aquaculture. It consists of live Yeast, Fermented Metabolites and Culture Fluids, with an emphasis in maximizing fermented metabolites. Even Its culture mediums and substrates for the fermentation were specially selected and processed ingredients. “AGRACULTURE” is fermented for 7 days or more (upto 11 days). Due to this long culturing period, “AGRACULTURE” contains many different nutritional factors in high levels. These are: Amino Acids, Vitamins, Flavor, Enzymes, Low pH (3.5 -4.5) etc., SPECIFICATIONS: Crude Protein: Min 20%, Crude Fiber: 13%, Moisture: 10 % max., Crude fat: 10% max. Crude Ash: 6% Max., pH: 3.5 – 4.5 INCLUSION RATE: Poultry and Swine: 1 to 2.5 kg /MT of feed. Bovine: 1 to 2 kg /MT of feed. Fish and Shrimp: 2kg /MT of feed. BENEFITS: Swine: Improvement in feed conversion ratio: 5% to 10 %. Average daily growth: 10%, Daily mean intake: 10%, Improvement in digestibility: 25%, Fast Growth: 10 days earlier for market weight. Poultry: Improvement in feed conversion ratio: 8%, Average daily growth: 5%, Egg production rate: 5 %, Improvement in Egg quality. P utility rate: 10%. Improvement daily feed intake: 10%. Prolong egg production period. Cattle: Improvement in Feed Conversion Ratio: 5 % to 10%. Average daily growth: 5 % to 10%. Improvement in daily feed intake: 10 % to 12 %. Better Digestion. Improvement in milk fat: 0.1% to 0.3 %. Improvement in milk production: 10% to 15 %. Fish and Shrimp: Improvement in digestion, resistance to disease and better feed conversion. All ingredients are approved by (FDA) and the American Association Of Feed Control Officals Offical Publicacion Year 2008
The natural way to fight disease WHAT IS ANVET ANVET is custom made blend of antibodies for any specie. The custom blend is made to the customer’s specifications in the type of antibody and the level of titer. ANVET comes in powder and paste form. In powder from it is administered directly into the feed or water. In paste form is administered orally to large animals. on the recommendation of the attending veterinarian. MODE OF ACTION With modern technical innovations in immunology, we are now able to produce individual antibodies at given levels (titer) for many of the intestinal pathogens that invade young animals. These antibodies can be blended and orally fed to insure that each animal receive an adequate oral dose. If given within a few hours after birth, the young animals can absorb these antibodies and have passive immunity. Older animals can be fed antibodies to displace pathogens from the gut. Animals need a minimum amount of beneficial bacteria (micro-flora) in order to maintaining a normal digestion and also be protected against pathogens. Normally, when pathogens enter the intestinal tract, they tend to compete with the micro-flora in occupying inner intestinal surface (competitive exclusion). This creates an imbalance in the intestinal micro-flora reducing the dominant presence of lactic acid producing bacteria. In this situation, natural antibodies, specific against predominant pathogens in the animal. Attach themselves to their specific their specific pathogens. In this way, the antibodies inhibit the infectious action of the pathogens, which are then excreted, thus preventing animal infection. TYPE OF ANTIBODIES E.Coli k88, 987p (1024 T, F-18 256 T, Porcine Rotavirus 1024T type 1 and 2, 1024T, Coronavirus 1024T, Cryptosporidia 512T , Clostridia Perfringens 1024 T, TGE 1024 T, Salmonella Dublins 1024 T, S.thyphimorium 256 T, S enteritidis 1024 T, S. Anatum 256 T. Circovirus 512 T, PED 640, 0157, 0-141 and 64,000. PACKAGING Pastes – 300 gr and 30 gr plastic tubes in 25 to 50 tubes per carton box. Powder – 500 gr pouches in 20 kg carton boxes. CARRIER In paste form, vegetable oil. In powder from, malt dextrin
Blend of Natural Antibodies and Probiotics for Swine and Bovine feeds. TECHNICAL SUMMARY What is Biofeed? Biofeed ® is a blend of beneficial bacteria and antibodies of natural origen extracted from dehydrated eggs for swine and bovine animals; both, designed to provide the animals with adequate microflora and host specific antibodies against predominant pathogens in each specie. Biofeed is available for both, swine and bovine species. Mode of Action Today''''''''s most modern technology in immunology allow the production of host specific antibodies at prescribed levels of titer designed to combat important predominant pathogens that invade the digestive tract of young animals. These antibodies can be blended and orally administered to insure that each animal receive the prescribed dossage needed. In new born animals, these antibodies are assimilated by the animal, immediately creating a passive immunity. In older animals, the antibodies displace the pathogens in the intestinal tract, resulting in the expulsión of these pathogens to the outside via the excrement. Generally, animals need a minimum quantity of beneficial bacteria (microflora), to absorb nutrients in the intestinal tract and to produce substances needed in normal digestion and in the protection of the animal against predominant pathogens. Normally, when pathogens enter the digestive tract, they tend to compete against microflora in occupying internal intestinal surface. (Competitive Exclusion). This create an imbalance in the intestinal microflora, reducing the presence of lactic acid producing bacteria. In this situation, the beneficial bacteria (microflora) have been replaced by prodominant pathogens, resulting in animal infection. The components in Biofeed® provide the animal with both, beneficial bacteria needed to maintain a normally balanced microflora and an adequate concentration of natural antibodies, against predominant pathogens. These antibodies attach to the outer membrane of predominant pathogens, in turn preventing these pathogens, from attaching to corresponding intestinal receptors located at the surface of the inner intestinal wall of the animals. Antibodies, also prevent the reproduction of these pathogens. Ultimately, these pathogens are inhibited and expelled to the outside, thus preventing animal disease. Method of Application Biofeed® can be administered both, as a preventive and therapeutic treatment. Providing probiotics only to the animal, almost always, result in the infection returning in 48 hours. However, when spesific antibodies are also provided as in Biofeed ® , a complete elimination of the infection is assured. Composition BIOFEED ® Swine: E.Coli k88, E.Coli K99, E.Coli K987p, E.Coli F-18. Porcine Rotavirus BIOFEED ® Bovine: E.Coli k99, Bovine Rotavirus Type 6 and type 10, Bovine Corona Virus, Salmonella Dublin, Salmonella Thyphimorium For Both: Probiotics (Host Specific): Lactobacillus Acidophylus, Bifedobacterium Longhum, Bifedobacterium Thermophylum, Streptococcus Faecium. Rates of application BIOFEED ® Swine (paste) with VIT-EXPRESS - In new born pigglets: 3 grams (once) per animal at birth. (In paste form). - In growing pigs with diarrhea: 15 grams per application, every 6 to 8 hour, as hended. - In pregnant and lactating mothers: HYDROENZIME - 100 grams. per MT of feed. BIOFEED ® Swine ( powder) - In swine after weaning: 70 to 100 grams per MT of feed during 8 days after weaning, thereafter: HYDROENZIME - 100 grams/MT -Pregnant and lacting mothers: HYDROENZIME - 100GRAMS / MT of feed. BIOFEED ® Bovine ( powder) - In newborne calves: : At arrival: 5 grams as son as possible as a drench. Mix 5 grams of BIOFEED in 20 cc of water. * From day 1 to day 3 ( Inclusive): 1,5 grams per calf per feeding in the milk. * From day 4 to day 15: 0.75 grams per calf per feeding in the milk. The criteria is to use this level until the calf is past the scouring stage and onto a good start. * From day 16 to weaning: 0.2 grams per calf in the AM feeding. Sick o scouring calves usually respond well with a additional 5 grsms per day for 2-3 days. This can be given in the milk or as a drench. All ingredients in BIOFEED are approved by FDA under the AFCO PUBLICATION 1,998 ( AMERICAN FEED CONTROL OFFICIALS ) Page 204 to page 215.
For Animal Feeds TECHNICAL SUMMARY What is CHELAGRA Copper? CHELAGRA Copper is a nutritional mineral feed supplement , in the form of copper that results from the chelation of soluble salts with amino acids and/or partially hydrolyzed protein . Mode of actionCHELAGRA Copper The amount of complexation between copper and protein provide for a maximum effect of copper as a nutritional supplement , as it is protected from degradation by the chelation complexation. Rate of application SWINES, LAYERS, BROILERS AND TURKEYS: 225grams per MT of feed. DAIRY AND BEEF CATTLE: 2 gr/head , daily. Or 1 kg / 500 heads daily. HORSES: 2 gr / head daily. SHEEP: 2.5 grams / 400 heads daily. CHELAGRA Copper Specifications ASSAY: Copper–10 % Min. Crude Protein- 30%, Crude Fat- 1%, Crude Fiber – 2% , Moisture- 5%. DENSITY – 0. 929 gm / cubic cm. CHELAGRA Copper Application Nutritional supplement in chemically stable form for livestock, poultry, aquaculture and pet food. Packaging and storage 25 kg poly-lined bags in export carton boxes. Store in dry area, under roof at ambient temperature. Store inside , in dry place and away fro sunlight. Shelf life- 3 years approx. Advantages in using CHELAGRA Copper Prevent mineral – mineral interactions Prevent mineral interactions with non-mineral compounds Achieve constant bio-availability in varying rations Supply amino acids Post Rumen Benefits in using CHELAGRA Copper Unsusceptible to micro-flora degradation Retained to a greater degree that their inorganic form. Elicit beneficial production response Characterized feed or production /management situations when chelates would induce a positive response. All ingredients approved by (FDA) under American Association of Feed Control Officials under Official (AAFCO) No. 57.150. Publication: 1,998.
For Animal Feeds TECHNICAL SUMMARY What is CHELAGRA ZINC? CHELAGRA ZINC is a nutritional mineral feed supplement , in the form of zinc that results from the chelation of soluble salts with amino acids and/or partially hydrolyzed protein. Mode of action CHELAGRA ZINC The amount of complexation between zinc and protein provide for a maximum effect of zinc as a nutritional supplement , as it is protected from degradation by the chelation complexation. Rate of application SWINES, LAYERS, BROILERS AND TURKEYS: 225grams per MT of feed. DAIRY AND BEEF CATTLE: 2 gr/head , daily. Or 1 kg / 500 heads daily. HORSES: 2 gr / head daily. SHEEP: 2.5 grams / 400 heads daily. CHELAGRA ZINC Specifications ASSAY: Zinc –15% Min. Crude Protein- 50%, Crude Fat- 1%, Crude Fiber – 2% , Moisture- 5%. DENSITY – 0.897 gm / cubic cm. CHELAGRA ZINC Application Nutritional supplement in chemically stable form for livestock, poultry, aquaculture and pet food. Packaging and storage 25 kg poly-lined bags in export carton boxes. Store in dry area, under roof at ambient temperature. Store inside , in dry place and away fro sunlight. Shelf life- 3 years approx. Advantages in using CHELAGRA ZINC Prevent mineral – mineral interactions Prevent mineral interactions with non-mineral compounds Achieve constant bio-availability in varying rations Supply amino acids Post Rumen Benefits in using CHERLAGRA ZINC Unsusceptible to micro-flora degradation Retained to a greater degree that their inorganic form. Elicit beneficial production response Characterized feed or production /management situations when chelates would induce a positive response. All ingredients approved by (FDA) under American Association of Feed Control Officials under Official (AAFCO) No. 57.150. Publication: 1,998.
What is Endure? Endure is a blend of dry distilled organic acids and soft carbon powder extracted from the bark of evergreen Broad-leaved trees. Endure is a natural coccidiostat and bactericide for poultry, swine and bovine rations. Mode of action: Soft carbon powder absorbs microorganism and distilled organic acids inhibit multiplication of pathogenic microorganism and promotes multiplication of lactic acid-producing bacteria. Mode of action: Soft carbon powder absorbs microorganism and distilled organic acids inhibit multiplication of pathogenic microorganism and promotes multiplication of lactic acid-producing bacteria. Soft carbon The crystal lattice of soft wood carbon in endure has an absorbing effect on Campylobacter, Cryptosporidium, Influenza Virus, salmonella, etc. Distilled organic acids: The distilled organic acids in Endure have a bactericidal effect in E. Enteritidis, Campilobacter, Cryptosporidium, etc. Intestinal Microflore The presence of ENDURE in the intestinal micro-flora promotes proliferation of beneficial lactic acid producing bacteria, such as lactobacillus Acidophilus, bifidus bacteria the organisms such as helping to balance micro-flora. Benefits: ENDURE promotes gut functions, establishes a barrier against foreign pathogens, activates the immune system against stress Other benefits: ENDURE prevents the multiplication of harmful bacteria, thus helps prevents diarrhea, inhibits the production of decay products and toxins produced be harmful bacteria, helps produce substances that maintain the functions of the digestive tract, and improve intestinal movement and contribute to prevention of constipation. Stronger immune response to disease. Economic benefits: ENDURE improves productivity indexes in poultry , swine and bovine, preventing digestive disorders, reduced weight gain and immune disfunctions, among others. Dosages: Bovine: 4 gr/h/day, Five days after weaning, Swine: 80 gr/MT of feed for 12 days after weaning, Poultry: 50 gr / MT of feed for last 35 days of cycle Endure characteriscis: Appearance: Natural Fine powder, Black color, Slightly Wood Vinegar Composition: Wood Carbon- 80% Wood Vinegar: 20% Bromatological Analysis: Crude Fiber-41.7 %,Crude Ash-12.90 %,Crude Protein-5.7 %,Crude Fat-0.20%,Calcium-2.90 %,Phosphoprous-0.06 %, Moisture-30.5% All ingredients approved by (FDA) and American Feed Control Officials under G.R.A.S classification AGRANCO CORP.(USA) Coral Gables. Fl. USA
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