Aflatoxin adsorption

Clays beyond aflatoxin adsorption. D. Zaviezo (Special Nutrients Inc)

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Date: Tuesday, March 29, 2011
Description:

Douglas Zaviezo, Special Nutrients´ Technical Director, gave a lecture about Clays beyond aflatoxin adsorption at Mycotoxins 2011, a one day technical conference held at the Imperial Queen´s Park Hotel in Bangkok, Thailand.

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Amit Nagpal
President
Re: Clays beyond aflatoxin adsorption. D. Zaviezo (Special Nutrients Inc)
15/08/2011 | Sir,

How can we Lab check the effeciency of any clay binder to prevent various mycotixins. Basically we are intrested the Method of Lab Analysis to confirm the efficiency of Varoius Binders to Bind varoius toxins

Expecting your reply

Regards
Amit Nagpal
Douglas Zaviezo
Consultant
Florida, United States
Re: Clays beyond aflatoxin adsorption. D. Zaviezo (Special Nutrients Inc)
15/08/2011 | Dear Mr. Nagpal,

One of the most important conclusion of the work is that there is no correlation between laboratory tests and in vivo efficiency of anti-mycotoxin additive. Therefore, my recomendation is to set up a bio-assay using animals to really evaluate the efficacy of different binders. Laboratory tests of net adsorption efficacy could help in the developing of a new binder but it is not appropriate to confirm the efficiency of various binders; you must run the test with the animals or ask the different suppliers for the scientifical studies conducted against specific mycotoxin(s) in a determined species.

Regards,
Douglas Zaviezo
Re: Clays beyond aflatoxin adsorption. D. Zaviezo (Special Nutrients Inc)
08/12/2011 | invitro methodology for binding assay is only indicative about binding of mycotoxins though it simulates intestinal conditions like pH,however it is blackbox.How much effective a binder in binding feed mycotoxins invivo? and how much is absorbed? any methodology to analyse that?
Re: Clays beyond aflatoxin adsorption. D. Zaviezo (Special Nutrients Inc)
08/12/2011 | The main problem between in vitro and in vivo assays that in vivo systems, beside different pH conditions, the unspecific binding of feed components (e.g. fibre) is not known and nearly impossible to predict those effect. Therefore efficacy of a mycotoxin binder in vitro should be prove by in vivo trials, but in both cases a dose range trial series requires because the ratio between the absorbent and the mycotoxin also would be a critical point, in particular in the in vitro trials.
Re: Clays beyond aflatoxin adsorption. D. Zaviezo (Special Nutrients Inc)
22/03/2012 |

Thanks for the presentation, I would like to get a piece of advise on how I can treat and use our ordinary clay in toxin binding.

Kasaka Moses

Douglas Zaviezo
Consultant
Florida, United States
Re: Clays beyond aflatoxin adsorption. D. Zaviezo (Special Nutrients Inc)
23/03/2012 |

Dear Mr. Moses,

First step is to send the clay to an independent laboratory to run the in vitro test of net adsorption capacity for the most important mycotoxins affecting the animals. Use a high dosage of the clay; the equivalent of 5 or 10 kg/ton of feed. If any of the results show an adsorption capacity higher than 70%, then run an in vivo experiment to confirm if the clay is really working in the animals.

Regards,
Douglas Zaviezo

Dmitry Preobrazhensky
General Manager
Re: Clays beyond aflatoxin adsorption. D. Zaviezo (Special Nutrients Inc)
08/05/2013 |

Dear Mr. Zaviezo,
Please estimate the possibility of combination of mycotoxin and pellet binding features. What could the minimum dosage be predicted in the case of such combination for clays or aluminocilicates?
Thanks for your comments in advance,
Dmitry Preobrazhenskiy
DVM

Douglas Zaviezo
Consultant
Florida, United States
Re: Clays beyond aflatoxin adsorption. D. Zaviezo (Special Nutrients Inc)
08/05/2013 |

Dear Mr. Preobrazhensky,

Today most of the animal feeds are contaminated with more than one mycotoxin, therefore is even more difficult to prevent the toxic effects of all of them. Some combinations of micotoxins are synergistic, creating serious problems. In poultry a combination of Aflatoxin + ochratoxin or fumonisin or T-2 toxin or any combination of this four are really dangerous for the birds. In swine aflatoxin in combination with any Fusarium toxin ( DON, zearalenone, fumonisin, T-2 toxin) is extremely dangerous, since pigs are more sensitive to mycotoxins.

There are some very effective (in vivo) alumosilicates to prevent and control aflatoxin; few are working at 2.5 - 3.0 kg/ton and the majority at about 5.0 kg/ton. If any of the Fusarium toxin is also present then you need to use purify and activated phylosilicates which are effective (in vivo) at 1.0 - 2.0 kg/ton. Most of the time the best solution is the combination of these two type of binders: 2.5 kg + 1.0 kg per metric ton. When you select a mycotoxin binder look for those with Target Organ Protection (TOP products) which are the most effective one.

Regards,
Douglas Zaviezo

Re: Clays beyond aflatoxin adsorption. D. Zaviezo (Special Nutrients Inc)
29/08/2016 | I am doing invivo efficacy test of four crude clays as aflatoxin binders using rats. On the way, I am suspecting possibility of exaggerated performance due confounding effect of micro-nutrient supply from clay. How can I clear this?
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