Re: Forum: Importance of HSCAS (zeolite powder) in Toxin Binders
We have modified the in-vitro testing conditions for binder evaluation for our own purposes. Instead of adsorbing small amounts of mycotoxins (0.05 - 0.01 mg/L) we use realistic mycotoxin concentrations, where they start to cause economic damages (1 mg/L). We also do not use pH 3, because this is a very little to ask from a good binder. We use pH 6.5 from the very beginning and all the way through testing. What good is your binder if it binds toxins in the stomich, where transfer into the blood stream is minimized, and gives them back in the thin intestine, where actual nutrient and myxotoxin adsorption by the animal takes place? We also feel that this way we could find more usiversal binder candidates, also useful for ruminants (there is no acidic pH during the ruminant digestion).
Under these conditions the commercial mineral binders (we tried several from Belgium, Netherlands and Russia, also generic zeolite) perform quite poorly: they adsorb about 10% of DON, 10% of ochratoxin, 0% of T-2 and 30% of zearalenone.
Organic binders based on microbial and plant biomass look much better under our assay. We do not test for aflatoxins, because this type of toxins is studied in detail in literature. Yeast cell wall and its components are an adequate solution for it, though it has its own deficiences as far as other toxins.
This is why we are using biomass-based binders. We have an option to add HSCAS as a backup component, but in most cases we see no benefit to do this: HSCAS binds too little persentage of DON, OTA, T-2 and ZEN, most part of these mycotoxins still left unbound. And you have to add really a lot of HSCAS to the diet (5 kg/ton of feed) to make sure that you are fighting mycotoxins at economically troubling levels, not just analytically detectible levels, which cause no economic damages. For example, in broiler diets these economically significant mycotoxin levels are approxinately: DON - 5 mg/kg, OTA - 0.2 mg/kg, T-2 - 0.5 mg/kg, ZEN - 100 mg/kg.